ITEMS IN AFP WITH KEYWORD:
Targeted cancer therapies are chemotherapeutic agents that directly or indirectly attack a specific genetic biomarker found in a given cancer. Targeted oncology includes monoclonal antibodies, small molecule inhibitors, antibody-drug conjugates, and immunotherapy. Targeted oncology has improved survival by years for some incurable cancers; however, as few as 8% of patients with advanced cancer qualify for targeted drugs, and even fewer benefit. Other limitations include possible serious adverse effects. Immune related–adverse effects are common with immunotherapy, and more severe events can be fatal and require immediate intervention. Financial toxicities are an emerging problem for patients with cancer who are taking costly targeted therapies. Future directions for targeted oncology include tumor-agnostic drugs.
Night sweats are a nonspecific symptom that patients commonly experience but rarely discuss with their physicians without prompting. Conditions commonly associated with night sweats include menopause, mood disorders, gastroesophageal reflux disease, hyperthyroidism, and obesity. Serious causes should be considered when the history and physical examination do not reveal a specific cause.
Jun 1, 2019 Issue
Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer [Cochrane for Clinicians]
Low-molecular-weight heparin (LMWH), vitamin K antagonists, and direct oral anticoagulants, when used to prevent recurrent VTE, have a similar impact on all-cause mortality.
Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.
We all need to test wisely and weigh the risks and benefits of diagnostic imaging. Imaging—and testing in general—has real downsides, such as stumbling onto things you wish you had not.
Kidney cancer is one of the 10 most common cancers in the United States. Risk factors include hypertension, tobacco use, obesity, and acquired cystic kidney disease in the setting of end-stage renal disease. More than 50% of patients with renal cell carcinoma are asymptomatic and are diagnosed incidentally during thoracoabdominal imaging. Prompt evaluation of warning signs can improve prognosis, and active surveillance is an option for certain patients.
To support early identification and treatment, the American Cancer Society (ACS) has updated its 2008 guidance on counseling and referring patients at average risk of colorectal cancer (CRC) based on new evidence regarding screening options and the ever-changing risk of CRC.
The primary care physician's role in cancer treatment.
Patients with multiple myeloma may demonstrate presence of the disease through blood testing alone or nonspecific symptoms. Infection, adverse treatment effects, and complications are common and require close monitoring.
Studies show no deaths were prevented and 1 in 5 underwent a prostate biopsy for a false-positive test. Read more.