ITEMS IN AFP WITH KEYWORD:
If nondrug measures are unsuccessful for chronic idiopathic constipation, the choice of a pharmacologic agent should be based on cost, tolerability, and long-term adherence rather than efficacy, because the efficacy is similar among drugs and drug classes.
Oct 1, 2017 Issue
Laxatives for the Management of Childhood Constipation [Cochrane for Clinicians]
Polyethylene glycol (PEG) is superior to placebo (mean difference [MD] = 2.61 more stools per week; 95% confidence interval [CI], 1.15 to 4.08), lactulose (MD = 0.70; 95% CI, 0.10 to 1.31), and milk of magnesia (MD = 0.69; 95% CI, 0.48 to 0.89) at increasing the number of bowel movements per week at two to 12 weeks.
Find out which bulking agents, osmotic and stimulant laxatives, and stool softeners are most effective. Also, review key behavioral interventions that can help prevent constipation in this population.
Learn the differential diagnosis of constipation in children and effective treatments, such as parental education, behavior interventions, diet changes, and medications.
Photo Quiz presents readers with a clinical challenge based on a photograph or other image.
Dec 1, 2011 Issue
Management of Constipation in Patients Receiving Palliative Care [Cochrane for Clinicians]
There is insufficient evidence to recommend one laxative over another for the treatment of constipation in patients receiving palliative care. Methylnaltrexone can increase the frequency of bowel movements at four hours (odds ratio = 7.0; 95% confidence interval, 3.8 to 12.6) and at 24 hours (odds r...
Constipation is traditionally defined as three or fewer bowel movements per week. Risk factors for constipation include female sex, older age, inactivity, low caloric intake, low-fiber diet, low income, low educational level, and taking a large number of medications. Chronic constipation is classifi...
What are the effects of nondrug interventions, fiber supplements, and paraffin in adults with idiopathic chronic constipation? What are the effects of stimulant and osmotic laxatives? What are the effects of prostaglandin derivatives and 5-hydroxytryptamine 4 receptor agonists in persons with idiopathic chronic constipation?
Methylnaltrexone can temporarily relieve opioid-induced constipation in patients with advanced illness who have not responded to laxative treatment. However, it must be given by injection, is expensive, and has been studied only for short-term use.
Although bulk or osmotic laxatives are less expensive first options for treating patients with chronic idiopathic constipation, lubiprostone is an alternative for those who do not tolerate or respond to these agents, or in patients older than 65 years in whom tegaserod use is not recommended.