Deep Venous Thrombosis

Sep 1, 2013 Issue
D-dimer vs. Ultrasonography for DVT: Use Prediction Rule [POEMs]

Use the Wells criteria to determine the likelihood of deep venous thrombosis; patients at moderate to high risk should go straight to ultrasonography. Patients at low risk should have d-dimer testing, followed by ultrasonography only if the results are positive. This approach decreases the use of d-...

Jun 1, 2013 Issue
Aspirin Following Anticoagulation Therapy Prevents Recurrent VTE [POEMs]

Although this ASPIRE study was underpowered to detect a difference in the primary outcome, when the results were combined with those of the WARFASA trial, the data show that daily low-dose aspirin prevents recurrent VTE as well as major vascular events without increasing bleeding in patients who hav...

Apr 15, 2013 Issue
Updated Guidelines on Outpatient Anticoagulation [Article]

The American College of Chest Physicians provides recommendations for the use of anticoagulant medications for several indications that are important in the primary care setting. Warfarin, a vitamin K antagonist, is recommended for the treatment of venous thromboembolism and for the prevention of st...

Nov 15, 2012 Issue
Diagnosis of Deep Venous Thrombosis and Pulmonary Embolism [Article]

Venous thromboembolism manifests as deep venous thrombosis (DVT) or pulmonary embolism, and has a mortality rate of 6 to 12 percent. Well-validated clinical prediction rules are available to determine the pretest probability of DVT and pulmonary embolism. When the likelihood of DVT is low, a negativ...

Oct 15, 2012 Issue
Rivaroxaban (Xarelto) for Prevention of Thromboembolic Events [STEPS]

In patients at high risk of stroke because of nonvalvular atrial fibrillation, rivaroxaban is as safe and effective as warfarin. However, it should not be used in patients at risk of stroke for reasons other than nonvalvular atrial fibrillation until research shows its relative safety and effectiveness.

Jun 15, 2012 Issue
ACP Recommendations for VTE Prophylaxis in Hospitalized Patients [Practice Guidelines]

Most hospitalized patients have at least one risk factor for venous thromboembolism (VTE), such as pulmonary embolism or deep venous thrombosis. The American College of Physicians (ACP) has released guidelines on VTE prophylaxis in hospitalized, nonsurgical patients, including those with acute stroke.

Jan 15, 2012 Issue
Thromboembolism [Clinical Evidence Handbook]

What are the effects of treatments for proximal and isolated calf DVT? What are the effects of treatments for pulmonary embolism? What are the effects of interventions on oral anticoagulation management in persons with thromboembolism?

Feb 1, 2011 Issue
Recurrent Venous Thromboembolism [Article]

A previous venous thromboembolism is the most important risk factor for predicting recurrence of the condition. Several studies have shown that routine testing for inherited thrombophilias is not helpful in predicting the risk of recurrence or altering treatment decisions, and therefore is not cost-...

Feb 1, 2010 Issue
Leg Compression and Pharmacologic Prophylaxis for Venous Thromboembolism Prevention in High-Risk Patients [Cochrane for Clinicians]

Based on high-quality evidence, the Cochrane review showed that combining IPC with pharmacologic prophylaxis was more effective than a single preventative measure for preventing deep venous thrombosis (DVT), and more effective than IPC alone for preventing pulmonary embolism (PE).

Jun 15, 2008 Issue
Venous Thromboembolism During Pregnancy [Article]

Venous thromboembolism is the leading cause of maternal death in the United States. Pregnancy is a risk factor for deep venous thrombosis, and risk is further increased with a personal or family history of thrombosis or thrombophilia. Screening for thrombophilia is not recommended for the general po...

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