Apr 01, 2022 Issue
Why Physicians Should Not Prescribe Aducanumab for Alzheimer Disease [Editorials]

Guidance to clinicians about how to approach use of the Alzheimer treatment aducanumab (Aduhelm) and other newly approved medications.

Jan 01, 2022 Issue
PrecivityAD for Diagnosis of Alzheimer Disease [Diagnostic Tests: What Physicians Need to Know]

The PrecivityAD test is a widely available blood test for older persons with mild cognitive impairment and is marketed to aid in the diagnosis of Alzheimer disease. The APS produced by the test is accurate in predicting the likelihood of positive PET findings, which may reduce the need for amyloid P...

Jan 01, 2022 Issue
Preventing Cognitive Decline [Editorials]

Because of the lack of effective treatments, prevention remains the best strategy for reducing the burden of dementia. Rather than attempting to identify and intervene on early disease through screening, a primary prevention strategy seeks to prevent cognitive decline by addressing modifiable risk factors.

Jul 01, 2021 Issue
Pharmacologic Management of Agitation in Patients with Dementia [FPIN's Clinical Inquiries]

Selective serotonin reuptake inhibitors and risperidone are moderately effective at decreasing agitation in all types of dementia. Olanzapine and risperidone reduce dementia-related agitation much longer than placebo. Dextromethorphan/quinidine may be effective at reducing agitation in patients with dementia.

Mar 1, 2021 Issue
Structural MRI for the Early Diagnosis of Alzheimer Disease in Patients with MCI [Cochrane for Clinicians]

There is insufficient evidence to recommend structural brain magnetic resonance imaging to diagnose Alzheimer disease in patients with mild cognitive impairment.

Feb 1, 2021 Issue
Brief Cognitive Testing in the Detection and Diagnosis of Clinical Alzheimer-Type Dementia [Implementing AHRQ Effective Health Care Reviews]

In adults with suspected cognitive impairment, what is the utility of brief cognitive testing in detecting clinical Alzheimer-type dementia and distinguishing it from mild cognitive impairment or normal cognition?

Dec 1, 2020 Issue
Some Drugs Slightly Improve Cognition in People with Dementia; Effects on Behavioral or Psychological Symptoms Remain Unclear [POEMs]

Some treatments can improve cognition on research scales, but daily function will not be affected in a noticeable way. Managing behavioral or psychological issues with medication is not supported by current evidence

May 15, 2020 Issue
Nonpharmacologic Approaches Are Better Than Medication to Control Aggression and Agitation in Dementia [POEMs]

Nonpharmacologic approaches to agitation or aggression in patients with dementia are more effective than medication (e.g., haloperidol). Outdoor activities, multidisciplinary care, and massage and touch therapy with or without music are all effective.

Sep 15, 2019 Issue
Diagnosing Dementia and Clarifying Goals of Care [Lown Right Care: Reducing Overuse and Underuse]

A collaboration between AFP and the Lown Institute promotes a vision of delivering heath care that is based on the evidence, balanced in its approach, and focused on the patient.

May 1, 2019 Issue
Vaginitis, Coronary Artery Disease, Hypertension in Children, COPD, Alzheimer Disease [AFP Clinical Answers]

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

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