Feb 1, 2015 Issue
Benzodiazepines and Alzheimer Disease [AFP Journal Club]

Benzodiazepine exposure over the preceding five years seems to be associated with an increased likelihood of an Alzheimer disease diagnosis. A dose-response gradient also seems to exist.

Sep 1, 2014 Issue
Exercise Programs for Older Patients with Dementia [Cochrane for Clinicians]

There is some evidence that exercise improves cognitive function and the ability to perform activities of daily living in patients with dementia.

Jun 1, 2014 Issue
Should Family Physicians Routinely Screen Patients for Cognitive Impairment? Yes: Screening Is the First Step Toward Improving Care [Editorials: Controversies in Family Medicine]

Being able to anticipate and mitigate the potentially adverse outcomes of hospitalization in these patients should be reason enough to screen for cognitive impairment in the primary care setting.

Jun 1, 2014 Issue
Should Family Physicians Routinely Screen Patients for Cognitive Impairment? No: Screening Has Been Inappropriately Urged Despite Absence of Evidence [Editorials: Controversies in Family Medicine]

Dementia screening should not be exempt from the requirement that it first be shown to improve outcomes before being implemented in practice.

Jan 15, 2014 Issue
Dementia [Clinical Evidence Handbook]

What are the effects of treatments on cognitive, behavioral, and psychological symptoms of dementia (Alzheimer disease, Lewy body dementia, or vascular dementia)?

Jun 1, 2013 Issue
Vitamin D + Calcium = Placebo for Cognitive Decline [POEMs]

Calcium plus vitamin D is no better than placebo in preventing cognitive decline in women older than 65 years.

Jan 1, 2012 Issue
Antidepressants for Agitation and Psychosis in Patients with Dementia [Cochrane for Clinicians]

There are few high-quality studies examining the effectiveness of antidepressants for treating the neuropsychiatric symptoms of dementia. Although there is some evidence to support the use of the selective serotonin reuptake inhibitors (SSRIs) sertraline (Zoloft) and citalopram (Celexa), they should...

Oct 15, 2011 Issue
Evaluation of Suspected Dementia [Article]

As the proportion of persons in the United States older than 65 years increases, the prevalence of dementia will increase as well. Risk factors for dementia include age, family history of dementia, apolipoprotein E4 genotype, cardiovascular comorbidities, chronic anticholinergic use, and lower educa...

Jun 15, 2011 Issue
Treatment of Alzheimer Disease [Article]

Alzheimer disease is the most common form of dementia, affecting more than one-third of Americans older than 85 years. It is characterized by progressive memory loss and cognitive decline. Amyloid plaque accumulation, neurofibrillary tau tangles, and depletion of acetylcholine are among the patholog...

May 1, 2011 Issue
Preventing Dementia: Is There Hope for Progress? [Editorials]

Undoubtedly, there is an increasing need to clarify the modifiable risk factors for cognitive impairment. Because the prevalence of dementia doubles every five years, the global burden of dementia will increase significantly—an impact that warrants a more anticipatory approach to identifying modifia...

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