Sep 1, 2006 Issue
Cholinesterase Inhibitors for Alzheimer's Disease [Cochrane for Clinicians]

Cholinesterase inhibitors produce a small benefit on several cognitive and noncognitive function scales. Although data for patients with severe dementia are sparse, there is no evidence to suggest a difference in effectiveness among patients with mild, moderate, or severe dementia. Compared with pla...

Aug 1, 2006 Issue
Are Atypical Antipsychotics Safe in Patients with Alzheimer's Disease? [Cochrane for Clinicians]

Although the atypical antipsychotic medications risperidone (Risperdal) and olanzapine (Zyprexa) are modestly efficacious in reducing aggression, routine use is not justified. Both drugs are associated with serious adverse cerebrovascular events and extrapyramidal symptoms. Use of atypical antipsych...

Apr 1, 2006 Issue
Dementia With Lewy Bodies: An Emerging Disease [Article]

Dementia with Lewy bodies appears to be the second most common form of dementia, accounting for about one in five cases. The condition is characterized by dementia accompanied by delirium, visual hallucinations, and parkinsonism. Other common symptoms include syncope, falls, sleep disorders, and dep...

Mar 15, 2006 Issue
Older Adult Drivers with Cognitive Impairment [Article]

As the number of drivers with cognitive impairment increases, family physicians are more likely to become involved in decisions about cessation of driving privileges in older patients. Physicians who care for cognitively impaired older adults should routinely ask about driving status. In patients wh...

Feb 15, 2006 Issue
Behavior Disorders of Dementia: Recognition and Treatment [Article]

Psychosis may pose a greater challenge than cognitive decline for patients with dementia and their caregivers. The nature and frequency of psychotic symptoms varies over the course of illness, but in most patients, these symptoms occur more often in the later stages of disease. Management of psychos...

Jun 1, 2005 Issue
FDA Warns Against Off-Label Use of Antipsychotic Drugs [Practice Guidelines]

May 1, 2005 Issue
Initial Evaluation of the Patient with Suspected Dementia [Article]

Dementia is a common disorder among older persons, and projections indicate that the number of patients with dementia in the United States will continue to grow. Alzheimer's disease and vascular dementia account for the majority of cases of dementia. After a thorough history and physical examination...

Nov 1, 2004 Issue
Donepezil in the Treatment of Vascular Dementia [Cochrane for Clinicians]

Donepezil in a dosage of 10 mg daily provides a small benefit in patients with mild to moderate vascular dementia and generally is well tolerated.

Oct 1, 2004 Issue
Screening for Dementia [Putting Prevention into Practice]

Case study: RG, a 75-year-old, college-educated man, presents for an annual physical examination. His friend recently was diagnosed with Alzheimer’s disease. RG is concerned about his occasional memory lapses and is worried that he also has the disease.

Sep 15, 2004 Issue
Efficient Identification of Adults with Depression and Dementia [Article]

Family physicians must decide how to screen for depression or dementia and which patients to screen. Mental health questionnaires can be helpful. In practice-based screening, questionnaires are administered to all patients, regardless of risk status. In case-finding screening, questionnaires are adm...

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