Depression and Bipolar Disorder

May 1, 2020 Issue
Antidepressants Plus Benzodiazepines for Adults with Major Depression [Cochrane for Clinicians]

A combination of tricyclic antidepressants and benzodiazepines is more effective for major depression in adults than tricyclic antidepressants alone in the first four weeks of treatment.

Mar 15, 2020 Issue
Esketamine (Spravato) for Treatment-Resistant Depression [STEPS]

Esketamine is an in-office treatment for patients with a severe major depressive disorder to be used in addition to oral antidepressant therapy.

Mar 1, 2020 Issue
Music Therapy for Depression [Cochrane for Clinicians]

Moderate-quality evidence shows that music therapy added to standard care is more effective in the first three months than standard care alone for depressive symptoms based on clinician-rated outcomes and patient-reported outcomes.

Feb 15, 2020 Issue
Do Not Change Antidepressant Treatment Early Based on a Lack of Response [POEMs]

Do not be in a hurry to change treatment in patients with severe depression who do not respond to treatment within the first two weeks. Early response to treatment predicts eventual response or remission, but a lack of early response does not predict treatment failure.

Feb 1, 2020 Issue
Adverse Events of Pharmacologic Treatments of Major Depression in Older Adults [Implementing AHRQ Effective Health Care Reviews]

What are the adverse events of antidepressants prescribed to treat major depressive disorder in adults 65 years and older?

Dec 15, 2019 Issue
Augmentation of Antidepressant Treatment Offers Little Benefit [POEMs]

The available evidence that treatment-resistant depression (depression that is unresponsive to two different treatments of adequate dose and length) responds well to augmentation treatment (i.e., adding psychotherapy, lithium, or aripiprazole [Abilify] to current treatment) is weak.

Nov 15, 2019 Issue
Depression in Children and Adolescents: Evaluation and Treatment [Article]

Children older than 12 years should be screened for depression annually using a validated instrument. Although mild depression is often self-limited and can be managed with monitoring and support, persistent or more severe depression should be treated with psychotherapy and an antidepressant. These therapies used concurrently are more effective than either treatment alone.

Oct 1, 2019 Issue
Perinatal Depression: AAP Policy Statement on Recognition and Management [Practice Guidelines]

The American Academy of Pediatrics has released a policy statement regarding the integration of perinatal depression recognition and management into well-child visits.

Sep 15, 2019 Issue
Interventions to Prevent Perinatal Depression: Recommendation Statement [U.S. Preventive Services Task Force]

The USPSTF recommends that clinicians provide or refer pregnant and postpartum persons who are at increased risk of perinatal depression to counseling interventions.

Sep 15, 2019 Issue
Weak Evidence Supports Augmentation Therapy for Treatment-Resistant Depression [POEMs]

There is weak research to guide treatment decisions for patients who have not responded to two adequate courses of antidepressant treatment. One study of cognitive behavior therapy showed benefit over placebo.

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