Depression and Bipolar Disorder

Oct 01, 2021 Issue
Does Light Therapy Decrease Depression in Older Adults? [FPIN's Clinical Inquiries]

Light therapy appears to be mildly effective in treating depression in older adults, but ideal wavelength, intensity, and length of treatment are unknown.

Oct 01, 2021 Issue
Depression, Cervical Myelopathy, Diagnostic Imaging, Eating Disorders, Vitamin K Antagonists [AFP Clinical Answers]

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

Aug 01, 2021 Issue
Physical Activity and the Prevention of Depression [FPIN's Clinical Inquiries]

Physical activity appears to be associated with a lower risk of developing depression and depressive symptoms.

Jan 1, 2021 Issue
Medications for Treatment-Resistant Depression in Adults [Cochrane for Clinicians]

In patients with treatment-resistant depression, augmenting therapy with atypical antipsychotics can be effective.

Dec 1, 2020 Issue
Seasonal Affective Disorder: Common Questions and Answers [Article]

Seasonal affective disorder is characterized by depressive symptoms that occur at a specific time of year, typically fall or winter, with full remission at other times of year. First-line therapy for seasonal affective disorder includes light therapy, antidepressants, and cognitive behavior therapy, alone or in combination. If seasonal affective disorder recurs, long-term treatment or preventive intervention is typically indicated. Bupropion appears to have the strongest evidence supporting long-term use.

Nov 1, 2020 Issue
Treatment of Depression in Children and Adolescents [Implementing AHRQ Effective Health Care Reviews]

What are the benefits and harms of nonpharmacologic and pharmacologic treatments for depressive disorders in children and adolescents?

May 1, 2020 Issue
Antidepressants Plus Benzodiazepines for Adults with Major Depression [Cochrane for Clinicians]

A combination of tricyclic antidepressants and benzodiazepines is more effective for major depression in adults than tricyclic antidepressants alone in the first four weeks of treatment.

Mar 15, 2020 Issue
Esketamine (Spravato) for Treatment-Resistant Depression [STEPS]

Esketamine is an in-office treatment for patients with a severe major depressive disorder to be used in addition to oral antidepressant therapy.

Mar 1, 2020 Issue
Music Therapy for Depression [Cochrane for Clinicians]

Moderate-quality evidence shows that music therapy added to standard care is more effective in the first three months than standard care alone for depressive symptoms based on clinician-rated outcomes and patient-reported outcomes.

Feb 15, 2020 Issue
Do Not Change Antidepressant Treatment Early Based on a Lack of Response [POEMs]

Do not be in a hurry to change treatment in patients with severe depression who do not respond to treatment within the first two weeks. Early response to treatment predicts eventual response or remission, but a lack of early response does not predict treatment failure.

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