Oct 15, 2015 Issue
Levomilnacipran (Fetzima) for Major Depressive Disorder [STEPS]

Levomilnacipran should not be used in patients with mild to moderate depression until studies have proven its effectiveness. It is somewhat effective in patients with moderate to severe depression. The short-term adverse effect profile of levomilnacipran is similar to that of other SNRIs.

Oct 1, 2015 Issue
ACOG Releases Recommendations on Screening for Perinatal Depression [Practice Guidelines]

The American College of Obstetricians and Gynecologists (ACOG) has released recommendations on screening women for perinatal depression, with the purpose of increasing awareness of depression and lessening the effects it has on pregnant and post-partum women and their families.

Jul 15, 2015 Issue
Common Questions About the Pharmacologic Management of Depression in Adults [Article]

Get the latest information on which patients benefit most from treatment with antidepressants, how long therapy should continue, and the safety of antidepressants in older adults and in patients who are pregnant or breastfeeding.

Jul 1, 2015 Issue
Are Some Antidepressants Safer than Others Regarding Suicide Risk? [POEMs]

Mirtazapine (Remeron) and venlafaxine are associated with higher rates of completed suicide in primary care patients. Rates of suicide attempts and completion are similar with the use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.

Mar 1, 2015 Issue
Vortioxetine (Brintellix) for the Treatment of Depression [STEPS]

Current evidence does not support the routine use of vortioxetine in the treatment of depression. Family physicians most often encounter patients with mild to moderate depression, and vortioxetine has not been studied in this population. There is no clear benefit of using vortioxetine over other more affordable options in its class.

Feb 1, 2015 Issue
Screening for Suicide Risk in Adolescents, Adults, and Older Adults in Primary Care: Recommendation Statement [U.S. Preventive Services Task Force]

The U.S. Preventive Services Task Force (USPSTF) concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for suicide risk in adolescents, adults, and older adults in primary care.

Nov 15, 2014 Issue
Grief and Major Depression—Controversy Over Changes in DSM-5 Diagnostic Criteria [Editorials]

One of the more controversial revisions in the DSM-5, the elimination of the bereavement exclusion criterion for major depressive disorder (MDD), is discussed.

Jun 1, 2014 Issue
Psychosocial and Psychological Interventions for Preventing Postpartum Depression [Cochrane for Clinicians]

A range of prevention strategies can reduce the risk of postpartum depression, but more study is needed to determine which interventions are most effective.

Apr 1, 2014 Issue
Collaborative Care for Depression and Anxiety [Cochrane for Clinicians]

The collaborative care model is effective for treating adults with depression and/or anxiety using a multiprofessional approach to patient care, a structured management plan, scheduled patient follow-ups, and enhanced interprofessional communication.

Jan 15, 2014 Issue
No Effect of Vitamin D on Depressive Symptoms [POEMs]

Taken in aggregate, symptoms of depression do not improve in patients with low vitamin D levels when given vitamin D supplementation any more than when given placebo. There may be a benefit in patients with low vitamin D levels and mild to moderate depression.

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