Depression and Bipolar Disorder

Mar 15, 2016 Issue
Screening for Depression in Children and Adolescents: Recommendation Statement [U.S. Preventive Services Task Force]

The USPSTF recommends screening for major depressive disorder (MDD) in adolescents aged 12 to 18 years. Screening should be implemented with adequate systems in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up.

Nov 1, 2015 Issue
Citalopram Plus Methylphenidate Better Than Either Alone for Geriatric Depression [POEMs]

Combined treatment with citalopram plus methylphenidate provided faster improvement of depression symptoms in older patients with unipolar depression. Combined treatment was also more likely than either medication alone to lead to remission of depression at four weeks and 16 weeks.

Oct 15, 2015 Issue
Levomilnacipran (Fetzima) for Major Depressive Disorder [STEPS]

Levomilnacipran should not be used in patients with mild to moderate depression until studies have proven its effectiveness. It is somewhat effective in patients with moderate to severe depression. The short-term adverse effect profile of levomilnacipran is similar to that of other SNRIs.

Oct 1, 2015 Issue
ACOG Releases Recommendations on Screening for Perinatal Depression [Practice Guidelines]

The American College of Obstetricians and Gynecologists (ACOG) has released recommendations on screening women for perinatal depression, with the purpose of increasing awareness of depression and lessening the effects it has on pregnant and post-partum women and their families.

Jul 15, 2015 Issue
Common Questions About the Pharmacologic Management of Depression in Adults [Article]

Get the latest information on which patients benefit most from treatment with antidepressants, how long therapy should continue, and the safety of antidepressants in older adults and in patients who are pregnant or breastfeeding.

Jul 1, 2015 Issue
Are Some Antidepressants Safer than Others Regarding Suicide Risk? [POEMs]

Mirtazapine (Remeron) and venlafaxine are associated with higher rates of completed suicide in primary care patients. Rates of suicide attempts and completion are similar with the use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.

Mar 1, 2015 Issue
Vortioxetine (Brintellix) for the Treatment of Depression [STEPS]

Current evidence does not support the routine use of vortioxetine in the treatment of depression. Family physicians most often encounter patients with mild to moderate depression, and vortioxetine has not been studied in this population. There is no clear benefit of using vortioxetine over other more affordable options in its class.

Feb 1, 2015 Issue
Screening for Suicide Risk in Adolescents, Adults, and Older Adults in Primary Care: Recommendation Statement [U.S. Preventive Services Task Force]

The U.S. Preventive Services Task Force (USPSTF) concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for suicide risk in adolescents, adults, and older adults in primary care.

Nov 15, 2014 Issue
Grief and Major Depression—Controversy Over Changes in DSM-5 Diagnostic Criteria [Editorials]

One of the more controversial revisions in the DSM-5, the elimination of the bereavement exclusion criterion for major depressive disorder (MDD), is discussed.

Jun 1, 2014 Issue
Psychosocial and Psychological Interventions for Preventing Postpartum Depression [Cochrane for Clinicians]

A range of prevention strategies can reduce the risk of postpartum depression, but more study is needed to determine which interventions are most effective.

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