Jul 15, 2010 Issue
Screening and Treatment for Major Depressive Disorder in Children and Adolescents: Recommendation Statement [U.S. Preventive Services Task Force]

The U.S. Preventive Services Task Force (USPSTF) recommends screening adolescents (12 to 18 years of age) for major depressive disorder (MDD) when systems are in place to ensure accurate diagnosis, psychotherapy (i.e., cognitive behavioral or interpersonal), and follow-up.

Jul 1, 2010 Issue
Effectiveness of Antidepressants Compared with Placebo for Depression in Primary Care [Cochrane for Clinicians]

Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings.

May 15, 2010 Issue
Antidepressants for Initial Treatment of Depression [AFP Journal Club]

Which antidepressants should be used for the initial treatment of depression? This quality multiple-treatment meta-analysis gives physicians a good starting point for choosing an antidepressant. Sertraline and escitalopram should be considered first-line agents whereas bupropion, fluoxetine, paroxetine, and duloxetine were least tolerated.

Apr 15, 2010 Issue
Exercise, Yoga, and Meditation for Depressive and Anxiety Disorders [Article]

Anxiety and depression are among the most common conditions cited by those seeking treatment with complementary and alternative therapies, such as exercise, meditation, tai chi, qigong, and yoga. The use of these therapies is increasing. Several studies of exercise and yoga have demonstrated therape...

Nov 1, 2009 Issue
Depression in Post-MI Patients: An Opportunity for Primary Care [Editorials]

Aug 1, 2009 Issue
ACP Guideline on Second-Generation Antidepressants for Depression Treatment [Practice Guidelines]

The American College of Physicians (ACP) released a clinical guideline that gave recommendations for using second-generation antidepressants in the treatment of depressive disorders and accompanying symptoms in adults. Depressive disorders addressed in the guideline include major depressive disorder...

Jul 15, 2009 Issue
Treatment-Resistant Depression [Article]

Up to two thirds of patients with major unipolar depression will not respond to the first medication prescribed. Depression may be considered resistant to treatment when at least two trials with antidepressants from different pharmacologic classes (adequate in dose, duration, and compliance) fail to...

Sep 1, 2008 Issue
GLAD-PC Steering Group Releases Guidelines for the Management of Adolescent Depression in Primary Care [Practice Guidelines]

The Guidelines for Adolescent Depression in Primary Care (GLAD-PC) Steering Group developed the first evidence-based, expert consensus-derived guidelines for the management of adolescent depression by primary care physicians.

Aug 1, 2008 Issue
Aripiprazole as Adjunctive Therapy in Patients with Major Depressive Disorder [AFP Journal Club]

Does augmentation with aripiprazole help patients with major depressive disorder who have not responded to initial therapy? Adding aripiprazole to SSRIs or SNRIs did not significantly improve depression in this study. However, this study did not compare the study drug with a real-world scenario.

Jul 15, 2008 Issue
Screening Instruments for Depression [Point-of-Care Guides]

Although depression is common in the primary care setting, accurate identification of these patients is challenging. A variety of screening instruments for depression have been developed and validated. They range from relatively lengthy and complex instruments, such as the 21-item Beck Depression Inventory,1 to brief one-or two-item instruments.

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