Depression and Bipolar Disorder

Apr 1, 2014 Issue
Collaborative Care for Depression and Anxiety [Cochrane for Clinicians]

The collaborative care model is effective for treating adults with depression and/or anxiety using a multiprofessional approach to patient care, a structured management plan, scheduled patient follow-ups, and enhanced interprofessional communication.

Jan 15, 2014 Issue
No Effect of Vitamin D on Depressive Symptoms [POEMs]

Taken in aggregate, symptoms of depression do not improve in patients with low vitamin D levels when given vitamin D supplementation any more than when given placebo. There may be a benefit in patients with low vitamin D levels and mild to moderate depression.

Dec 15, 2013 Issue
Exercise Effective for Depression in Older Patients [POEMs]

An organized exercise program for older patients, which may include strength training, endurance training, or both, may be helpful for some patients with symptoms of depression. The results will not be striking, but exercise is an option for patients willing to participate.

Nov 15, 2013 Issue
Second-Generation Antidepressants for Depression in Adults [Implementing AHRQ Effective Health Care Reviews]

What are the comparative effectiveness and adverse effects of second-generation antidepressants for treating depression in adults?

Aug 15, 2013 Issue
Vilazodone (Viibryd) for the Treatment of Depression [STEPS]

The available evidence does not support the routine use of vilazodone in the treatment of depression. It is significantly more expensive than generic alternatives and is no more effective for moderate to severe depression than selective serotonin reuptake inhibitors or tricyclic antidepressants.

Dec 15, 2012 Issue
Depression in Children and Adolescents [Clinical Evidence Handbook]

What are the effects of pharmacological and psychological treatments for depression in children and adolescents? What are the effects of combination and complementary treatments for depression in children and adolescents? What are the effects of treatments for refractory depression in children and adolescents?

Dec 1, 2012 Issue
Seasonal Affective Disorder [Article]

Seasonal affective disorder is a combination of biologic and mood disturbances with a seasonal pattern, typically occurring in the autumn and winter with remission in the spring or summer. In a given year, about 5 percent of the U.S. population experiences seasonal affective disorder, with symptoms ...

Sep 1, 2012 Issue
Treatment of Childhood and Adolescent Depression [Article]

Major depressive disorder in children and adolescents is a common condition that affects physical, emotional, and social development. Risk factors include a family history of depression, parental conflict, poor peer relationships, deficits in coping skills, and negative thinking. Diagnostic criteria...

Aug 1, 2012 Issue
Managing Grief and Depression at the End of Life [Article]

Psychological distress is common in terminally ill persons and can be a source of great suffering. Grief is an adaptive, universal, and highly personalized response to the multiple losses that occur at the end of life. This response may be intense early on after a loss manifesting itself physically,...

Aug 1, 2012 Issue
Differentiating Grief and Depression in Patients Who Are Seriously Ill [Editorials]

Differentiating between grief and depression in a patient who is seriously ill is important because the management strategies for each condition are different. It can be difficult to distinguish between depression and grief because they have overlapping symptoms (i.e., sadness, crying, loss of appetite, weight, sleep) and may coexist.

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