Jan 1, 2007 Issue
Childhood and Adolescent Depression [Article]

Major depression affects 3 to 5 percent of children and adolescents. Depression negatively impacts growth and development, school performance, and peer or family relationships and may lead to suicide. Biomedical and psychosocial risk factors include a family history of depression, female sex, childh...

Nov 1, 2006 Issue
Seasonal Affective Disorder [Article]

Patients with seasonal affective disorder have episodes of major depression that tend to recur during specific times of the year, usually in winter. Like major depression, seasonal affective disorder probably is underdiagnosed in primary care settings. Although several screening instruments are avai...

Nov 1, 2006 Issue
Antidepressants in Older Persons [Cochrane for Clinicians]

In older persons with depression, three classes of antidepressants are equally effective: selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and tricyclic-like compounds. More patients taking classic tricyclic antidepressants stopped their medications because of adverse even...

Aug 1, 2006 Issue
Antidepressant Discontinuation Syndrome [Article]

Antidepressant discontinuation syndrome occurs in approximately 20 percent of patients after abrupt discontinuation of an antidepressant medication that was taken for at least six weeks. Typical symptoms of antidepressant discontinuation syndrome include flu-like symptoms, insomnia, nausea, imbalanc...

Jun 1, 2006 Issue
Pharmacologic Treatment of Psychotic Depression [Cochrane for Clinicians]

An antidepressant such as imipramine (Tofranil) or sertraline (Zoloft), possibly with the addition of an antipsychotic, is the preferred initial pharmacologic treatment for psychotic depression.

May 1, 2006 Issue
Screening for Depression [Cochrane for Clinicians]

Sensitive and specific screening tools and effective treatments are available for depression. However, screening for depression has not been shown to increase the number of patients who receive treatment or to improve patient outcomes. This may be because the positive predictive values of screening ...

Jan 1, 2006 Issue
Cognitive Therapy for Depression [Article]

Cognitive therapy is a treatment process that enables patients to correct false self-beliefs that can lead to negative moods and behaviors. The fundamental assumption is that a thought precedes a mood; therefore, learning to substitute healthy thoughts for negative thoughts will improve a person's m...

Dec 1, 2005 Issue
St. John's Wort [Article]

St. John's wort has been used to treat a variety of conditions. Several brands are standardized for content of hypericin and hyperforin, which are among the most researched active components of St. John's wort. St. John's wort has been found to be superior to placebo and equivalent to standard antid...

Oct 1, 2005 Issue
Postnatal Depression [Clinical Evidence Handbook]

What are the effects of drug and nondrug treatments?

Sep 15, 2005 Issue
Duloxetine (Cymbalta) for Treatment of Major Depressive Disorder [STEPS]

Duloxetine is safe and effective for the treatment of major depressive disorder. Because of its expense and the lack of data supporting its superiority over other antidepressants, it should be used as an alternative if other agents are ineffective or are not tolerated.

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