Feb 1, 2005 Issue
Antidepressants and Antiepileptic Drugs for Chronic Non-Cancer Pain [Article]

The development of newer classes of antidepressants and second-generation antiepileptic drugs has created unprecedented opportunities for the treatment of chronic pain. These drugs modulate pain transmission by interacting with specific neurotransmitters and ion channels. The actions of antidepressa...

Oct 1, 2004 Issue
Optimal Dosage of Tricyclic Antidepressants [Cochrane for Clinicians]

Although the quality of the data limits the strength of the recommendation, current evidence shows that 75 to 100 mg per day of a tricyclic antidepressant is more effective than placebo. Higher dosages are not more effective and are associated with more dropouts because of side effects.

Sep 15, 2004 Issue
Efficient Identification of Adults with Depression and Dementia [Article]

Family physicians must decide how to screen for depression or dementia and which patients to screen. Mental health questionnaires can be helpful. In practice-based screening, questionnaires are administered to all patients, regardless of risk status. In case-finding screening, questionnaires are adm...

May 15, 2004 Issue
Depression in Later Life: A Diagnostic and Therapeutic Challenge [Article]

Depression in elderly persons is widespread, often undiagnosed, and usually untreated. The current system of care is fragmented and inadequate, and staff at residential and other facilities often are ill-equipped to recognize and treat patients with depression. Because there is no reliable diagnosti...

Dec 1, 2003 Issue
Escitalopram (Lexapro) for Depression. [STEPS]

While escitalopram has proved to be an effective treatment for major depression, it has not been shown to be significantly more effective, safer, or better tolerated than citalopram or other antidepressants.

Apr 15, 2003 Issue
Premenstrual Syndrome [Article]

Premenstrual syndrome, a common cyclic disorder of young and middle-aged women, is characterized by emotional and physical symptoms that consistently occur during the luteal phase of the menstrual cycle. Women with more severe affective symptoms are classified as having premenstrual dysphoric disord...

Apr 1, 2003 Issue
Screening for Depression [Putting Prevention into Practice]

Case study: Your office is reviewing its disease screening policies and procedures, and you wonder if depression screening should be included. You are concerned about the effectiveness of screening, your partners' comfort with depression diagnosis and treatment, and the amount of time screening would take.

Feb 1, 2003 Issue
Depression in Children and Adolescents [Clinical Evidence Handbook]

What are the effects of treatments for depression in children and adolescents? Which treatments are effective to improve long-term outcomes?

Feb 1, 2003 Issue
Antidepressants: Update on New Agents and Indications [Article]

A number of antidepressants have emerged in the U.S. market in the past two decades. Selective serotonin reuptake inhibitors have become the drugs of choice in the treatment of depression, and they are also effective in the treatment of obsessive-compulsive disorder, panic disorder, and social phobi...

Oct 1, 2002 Issue
Diagnosis and Treatment of Premenstrual Dysphoric Disorder [Article]

From 2 to 10 percent of women of reproductive age have severe distress and dysfunction caused by premenstrual dysphoric disorder, a severe form of premenstrual syndrome. Current research implicates mechanisms of serotonin as relevant to etiology and treatment. Patients with mild to moderate symptoms...

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