Depression and Bipolar Disorder

Jul 15, 2009 Issue
Treatment-Resistant Depression [Article]

Up to two thirds of patients with major unipolar depression will not respond to the first medication prescribed. Depression may be considered resistant to treatment when at least two trials with antidepressants from different pharmacologic classes (adequate in dose, duration, and compliance) fail to...

Sep 1, 2008 Issue
GLAD-PC Steering Group Releases Guidelines for the Management of Adolescent Depression in Primary Care [Practice Guidelines]

The Guidelines for Adolescent Depression in Primary Care (GLAD-PC) Steering Group developed the first evidence-based, expert consensus-derived guidelines for the management of adolescent depression by primary care physicians.

Aug 1, 2008 Issue
Aripiprazole as Adjunctive Therapy in Patients with Major Depressive Disorder [AFP Journal Club]

Does augmentation with aripiprazole help patients with major depressive disorder who have not responded to initial therapy? Adding aripiprazole to SSRIs or SNRIs did not significantly improve depression in this study. However, this study did not compare the study drug with a real-world scenario.

Jul 15, 2008 Issue
Screening Instruments for Depression [Point-of-Care Guides]

Although depression is common in the primary care setting, accurate identification of these patients is challenging. A variety of screening instruments for depression have been developed and validated. They range from relatively lengthy and complex instruments, such as the 21-item Beck Depression Inventory,1 to brief one-or two-item instruments.

Mar 15, 2008 Issue
Pharmacologic Management of Adult Depression [Article]

Major depression is a common and treatable disease. Many patients benefit from pharmacologic treatment and, because there is little variation in antidepressant effectiveness, medication choices should be made based on patient characteristics, safety, and anticipated side effects. Most patients respo...

Feb 15, 2008 Issue
Selegiline Transdermal Patch (Emsam) for Major Depressive Disorder [STEPS]

Transdermal selegiline is an expensive treatment option for patients with major depressive disorder who have not responded to other antidepressants or who cannot swallow or take oral medications. Based on guidelines from the American Psychiatric Association, MAO inhibitor pharmacotherapy should be r...

Jan 1, 2007 Issue
Childhood and Adolescent Depression [Article]

Major depression affects 3 to 5 percent of children and adolescents. Depression negatively impacts growth and development, school performance, and peer or family relationships and may lead to suicide. Biomedical and psychosocial risk factors include a family history of depression, female sex, childh...

Nov 1, 2006 Issue
Seasonal Affective Disorder [Article]

Patients with seasonal affective disorder have episodes of major depression that tend to recur during specific times of the year, usually in winter. Like major depression, seasonal affective disorder probably is underdiagnosed in primary care settings. Although several screening instruments are avai...

Nov 1, 2006 Issue
Antidepressants in Older Persons [Cochrane for Clinicians]

In older persons with depression, three classes of antidepressants are equally effective: selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and tricyclic-like compounds. More patients taking classic tricyclic antidepressants stopped their medications because of adverse even...

Aug 1, 2006 Issue
Antidepressant Discontinuation Syndrome [Article]

Antidepressant discontinuation syndrome occurs in approximately 20 percent of patients after abrupt discontinuation of an antidepressant medication that was taken for at least six weeks. Typical symptoms of antidepressant discontinuation syndrome include flu-like symptoms, insomnia, nausea, imbalanc...

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