Oct 01, 2021 Issue
Diabetes-Related Foot Infections: Diagnosis and Treatment [Article]

Diabetes-related foot infections occur in approximately 40% of diabetes-related foot ulcers and cause significant morbidity. Clinicians should consider patient risk factors (e.g., presence of foot ulcers greater than 2 cm, uncontrolled diabetes mellitus, poor vascular perfusion, comorbid illness) wh...

Oct 01, 2021 Issue
For Patients with Type 2 Diabetes Mellitus Who Are Taking a GLP-1 Receptor Agonist, an SGLT2 Inhibitor May Be Preferred to a Sulfonylurea as Add-on Therapy [POEMs]

This propensity score–matched analysis (not funded by industry) concluded that an SGLT2 inhibitor is preferred over a sulfonylurea for patients with type 2 diabetes who are already taking a GLP-1 receptor agonist, with favorable effects on the likelihood of hospitalization for myocardial infarction and heart failure, and all-cause mortality.

Sep 01, 2021 Issue
The Risk of Progression from Prediabetes to Diabetes in Older Adults Is Low [POEMs]

Older patients generally will not progress to diabetes; they will either, over an average of 6.5 years, stay at the prediabetic levels or revert to normal levels. If a patient makes it to their mid-70s without a diagnosis of diabetes, it is unlikely to occur.

Aug 01, 2021 Issue
SGLT2 Inhibitors or GLP-1 Receptor Agonists Reduce Cardiovascular Outcomes in Patients with Type 2 Diabetes [POEMs]

SGLT2 inhibitors, the diabetes medications ending in -flozin, and GLP-1 receptor agonists, the -tide medications, decrease cardiovascular and renal outcomes to a greater extent than placebo or other treatments. They should be considered in addition to metformin and other glucose-lowering treatments for most patients with type 2 diabetes.

Aug 01, 2021 Issue
Can Pioglitazone Prevent or Delay Type 2 Diabetes in Patients with Prediabetes? [Cochrane for Clinicians]

Pioglitazone prevents or delays the incidence of type 2 diabetes in individuals with prediabetes when compared with placebo (absolute risk reduction [ARR] = 11.3%; 95% CI, 0.9% to 15.6%; number needed to treat [NNT] = 9) or no intervention (ARR = 13.3%; 95% CI, 11.6% to 14.9%; NNT = 7). Compared wit...

Jul 01, 2021 Issue
Low-Carb Diets May Produce Short-Term Diabetes Remission [POEMs]

Patients with type 2 diabetes can try cutting out bread and pasta, leaving the skin on chicken, or eating nuts and avocados to lower their blood glucose levels. Six months of a low-carbohydrate diet (less than 26% of calories from carbohydrates) was more likely than other diets or usual diet to redu...

Jun 1, 2021 Issue
Chronic Kidney Disease in Diabetes: Guidelines from KDIGO [Practice Guidelines]

The Kidney Disease: Improving Global Outcomes (KDIGO) group, an international organization dedicated to nephrology clinical practice guidelines, has developed a new guideline for management of diabetes with chronic kidney disease.

Jun 1, 2021 Issue
Flash Continuous Glucose Monitoring (FreeStyle Libre 14-Day System) for Self-Management of Diabetes Mellitus [Diagnostic Tests: What Physicians Need to Know]

The use of FreeStyle Libre increases time in euglycemic range and decreases hyperglycemic and hypoglycemic time and events in adults with type 1 diabetes.

Jun 1, 2021 Issue
Continuous Glucose Monitoring Adds Little Benefit, Especially in Adults [POEMs]

In patients who have diabetes mellitus who are treated with intensive insulin regimens, continuous glucose monitoring modestly decreases A1C in short-term, unmasked studies.

Jun 1, 2021 Issue
Preoperative A1C Threshold in Patients with Diabetes [FPIN's Clinical Inquiries]

In patients with diabetes mellitus who are preparing for total joint replacement, what is the preoperative A1C goal to reduce postoperative periprosthetic joint infections?

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