May 1, 2005 Issue
Hyperosmolar Hyperglycemic State [Article]

Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose, hyperosmolarity, and little or no ketosis. With the dramatic increase in the prevalence of type 2 diabetes and the aging population, this condition may be encountered more frequently by ...

May 1, 2005 Issue
Diabetic Ketoacidosis [Article]

A diagnosis of diabetic ketoacidosis requires the patient's plasma glucose concentration to be above 250 mg per dL (although it usually is much higher), the pH level to be less than 7.30, and the bicarbonate level to be 18 mEq per L or less. Beta-hydroxybutyrate is a better measurement of the degree...

Apr 15, 2005 Issue
Improving the Quality of Care for Adults with Type 2 Diabetes Mellitus [Practice Guidelines]

Apr 1, 2005 Issue
IDSA Releases Guidelines on the Diagnosis and Treatment of Diabetic Foot Infections [Practice Guidelines]

Guidelines for the diagnosis and treatment of diabetic foot infections have been developed by the Infectious Diseases Society of America (IDSA). In persons with diabetes, foot infections can cause substantial morbidity and are the most common nontraumatic cause of amputations.

Mar 1, 2005 Issue
Insulin Monotherapy vs. Combination Therapy [Cochrane for Clinicians]

NPH insulin and metformin taken at bedtime appears to be the most favorable combination studied, but this conclusion is based on poor-quality, inconsistent studies that measure disease-oriented outcomes. There are no data on the effect of these drug combinations on patient-oriented outcomes.

Feb 15, 2005 Issue
ACS/ADA/AHA Issue Core Recommendations for Preventing Cancer, Cardiovascular Disease, and Diabetes [Practice Guidelines]

The American Cancer Society (ACS), the American Diabetes Association (ADA), and the American Heart Association (AHA) have issued core recommendations for the prevention and early detection of cancer, cardiovascular disease, and diabetes.

Dec 1, 2004 Issue
Link Between Metformin and Lactic Acidosis? [Cochrane for Clinicians]

There is no evidence that metformin causes lactic acidosis, even in patients with renal insufficiency or other comorbidities. Although caution is still indicated in patients with multiple or severe comorbidities, it appears that the initial concern about lactic acidosis with this drug was misplaced.

Aug 15, 2004 Issue
ACP Releases Guideline on Lipid Control in Patients with Type 2 Diabetes Mellitus [Practice Guidelines]

A guideline on the management of dyslipidemia, particularly hypercholesterolemia, in patients with type 2 diabetes mellitus has been published by the Clinical Efficacy Assessment Subcommittee of the American College of Physicians (ACP).

Aug 1, 2004 Issue
Insulin Therapy for Type 2 Diabetes: Rescue, Augmentation, and Replacement of Beta-Cell Function [Article]

Type 2 diabetes is characterized by progressive beta-cell failure. Indications for exogenous insulin therapy in patients with this condition include acute illness or surgery, pregnancy, glucose toxicity, contraindications to or failure to achieve goals with oral antidiabetic medications, and a need ...

Apr 15, 2004 Issue
Impaired Glucose Tolerance and Impaired Fasting Glucose [Article]

Impaired glucose tolerance and impaired fasting glucose form an intermediate stage in the natural history of diabetes mellitus. From 10 to 15 percent of adults in the United States have one of these conditions. Impaired glucose tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL ...

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