Nov 1, 2009 Issue
Low Glycemic Index Diets for the Management of Diabetes [Cochrane for Clinicians]

The low glycemic index diet (sometimes called a low glycemic load diet) lowered the A1C level by a weighted mean difference of 0.5 percent when compared with a high glycemic index (or glycemic load) diet. Fewer episodes of hypoglycemia occurred with a low glycemic index diet compared with a high glycemic index diet.

Oct 15, 2009 Issue
Diabetes: Foot Ulcers and Amputations [Clinical Evidence Handbook]

What are the effects of interventions to prevent foot ulcers and amputations in persons with diabetes? What are the effects of treatments in persons with diabetes with foot ulceration?

Sep 1, 2009 Issue
Type 2 Diabetes: Separating Proven from Unproven Interventions [Editorials]

Jul 15, 2009 Issue
Risk-Assessment Tools for Detecting Undiagnosed Diabetes [Point-of-Care Guides]

Early intervention with lifestyle modifications or pharmacotherapy has been shown to effectively delay or prevent type 2 diabetes in adults.

Mar 1, 2009 Issue
Dipeptidyl-peptidase-4 Inhibitors for Treatment of Type 2 Diabetes [Cochrane for Clinicians]

When used as monotherapy or in conjunction with metformin (Glucophage) or thiazolidinediones, the DPP-4 inhibitor sitagliptin (Januvia) decreases A1C levels by 0.7 percent, but there are no data on patient-oriented outcomes or long-term safety. Until more studies are completed, it should only be use...

Jan 1, 2009 Issue
Management of Blood Glucose in Type 2 Diabetes Mellitus [Article]

Evidence-based guidelines for the treatment of type 2 diabetes mellitus focus on three areas: intensive lifestyle intervention that includes at least 150 minutes per week of physical activity, weight loss with an initial goal of 7 percent of baseline weight, and a low-fat, reduced-calorie diet; aggr...

Jul 15, 2008 Issue
Becaplermin (Regranex) for Diabetic Foot Ulcers [STEPS]

Although patients treated with becaplermin are more likely to experience complete and faster ulcer healing than patients continuing good wound care alone, the increased risk of cancer mortality and significant cost outweigh the possible benefits in most patients.

Jul 1, 2008 Issue
Diabetic Foot Infection [Article]

Foot infections are common in patients with diabetes and are associated with high morbidity and risk of lower extremity amputation. Diabetic foot infections are classified as mild, moderate, or severe. Gram-positive bacteria, such as Staphylococcus aureus and beta-hemolytic streptococci, are the mos...

Jun 15, 2008 Issue
Gastrointestinal Complications of Diabetes [Article]

Gastrointestinal complications of diabetes include gastroparesis, intestinal enteropathy (which can cause diarrhea, constipation, and fecal incontinence), and nonalcoholic fatty liver disease. Patients with gastroparesis may present with early satiety, nausea, vomiting, bloating, postprandial fullne...

Feb 15, 2008 Issue
Are Long-acting Insulin Analogues Better Than Isophane Insulin? [Cochrane for Clinicians]

Based on poor quality evidence, this review suggests that insulin glargine and insulin detemir have no advantage over isophane insulin in reducing A1C levels. In one study, isophane insulin reduced A1C levels slightly more than insulin detemir. However, patients on insulin glargine and detemir repor...

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