May 15, 2014 Issue
Glycemic Control in Type 2 Diabetes (Drug Treatments) [Clinical Evidence Handbook]

What are the effects of blood glucose–lowering medications in adults with type 2 diabetes?

Feb 15, 2014 Issue
“Lending a Hand” to Patients with Type 2 Diabetes: A Simple Way to Communicate Treatment Goals [Editorials]

A new approach to the care of adults with type 2 diabetes emphasizes proven interventions that improve duration and quality of life.

Jan 15, 2014 Issue
Fewer Deaths/Strokes/Revascularizations with Metformin Than Glipizide [POEMs]

Over five years, treatment with metformin for three years, with other hypoglycemics as needed, reduced the likelihood of death, nonfatal stroke, or the need for vascularization compared with treatment beginning with glipizide (Glucotrol). Cardiovascular events were not individually reduced with metformin compared with glipizide.

Dec 15, 2013 Issue
Intensive Lifestyle Intervention Fails to Improve Patient-Oriented Outcomes in Persons with Obesity and Diabetes [POEMs]

This large, well-designed trial failed to find a statistically significant improvement in patient-oriented outcomes in patients with diabetes, despite a fairly intensive lifestyle intervention and long-term follow-up.

Nov 15, 2013 Issue
AAP Releases Guideline on Managing Type 2 Diabetes Mellitus in Patients 10 to 18 Years of Age [Practice Guidelines]

Childhood type 2 diabetes poses a challenge to many physicians who are not used to treating this disease in such young patients. The American Academy of Pediatrics (AAP) has released a guideline of evidence-based recommendations for treating type 2 diabetes in patients 10 to 18 years of age. The gui...

Sep 1, 2013 Issue
Aliskiren Worsens Outcomes in High-Risk Patients with Diabetes [POEMs]

Aliskiren increases the likelihood of adverse cardiovascular outcomes in patients with diabetes and kidney or heart disease, and cannot be recommended.

Aug 1, 2013 Issue
Diabetic Foot Infections [Article]

Diabetic foot infection, defined as soft tissue or bone infection below the malleoli, is the most common complication of diabetes mellitus leading to hospitalization and the most frequent cause of nontraumatic lower extremity amputation. Diabetic foot infections are diagnosed clinically based on the...

May 15, 2013 Issue
Bromocriptine Mesylate (Cycloset) for Type 2 Diabetes Mellitus [STEPS]

Cycloset will lower A1C levels by 0.3 to 0.5 percent when taken alone or in combination with a sulfonylurea, without undesirable adverse effects such as hypoglycemia and weight gain. It will not cause further improvement of glucose control when used with insulin, metformin, or other hypoglycemic age...

Apr 15, 2013 Issue
Metformin Use in Adolescents [FPIN's Clinical Inquiries]

There are no studies evaluating whether metformin prevents or delays the onset of diabetes in adolescents who are obese. In adults, metformin is as effective as lifestyle interventions in preventing increases in A1C and fasting glucose levels, but it is less effective in preventing or delaying the o...

Apr 15, 2013 Issue
Diabetes: Treating Hypertension [Clinical Evidence Handbook]

What are the effects of antihypertensives and different blood pressure targets in persons with diabetes and hypertension?

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