Drug Adverse Effects

Jun 1, 2018 Issue
How the FDA Ensures High-Quality Generic Drugs [Editorials]

We want to assure all stakeholders of the rigorous approval process that supports the FDA's commitment to ensuring the high quality of generic drugs marketed in the United States.

Sep 1, 2017 Issue
White Spot on the Wrist [Photo Quiz]

A woman presented with an asymptomatic white patch on the right wrist that appeared two months earlier.

Aug 15, 2017 Issue
No Increased Risk of ASD, ADHD, or SGA with First-Trimester Antidepressant Use [POEMs]

This study found that maternal antidepressant use during the first trimester of pregnancy is associated with an increased risk of preterm birth, but not SGA, ASD, or ADHD. Another study in the same issue also reported no increased risk of ASD with in utero exposure to selective serotonin reuptake in...

Jan 1, 2016 Issue
Skin Ulcers of Unknown Etiology [Photo Quiz]

A woman with a long history of cocaine use presented to the emergency department with leg ulcers and ecchymoses on her ears.

Nov 1, 2015 Issue
Risk Evaluation and Mitigation Strategy (REMS): FDA Perspective on What Physicians Need to Know [Editorials]

For some drugs, risk mitigation measures beyond FDA-approved labeling are deemed necessary. Learn more about these Risk Evaluation and Mitigation Strategies (REMS).

Aug 1, 2015 Issue
Hyperpigmented Plaques on the Feet [Photo Quiz]

A man presented with asymptomatic blue-gray lesions on both feet that were darkening over time. He was using several medications.

Jul 1, 2015 Issue
Are Some Antidepressants Safer than Others Regarding Suicide Risk? [POEMs]

Mirtazapine (Remeron) and venlafaxine are associated with higher rates of completed suicide in primary care patients. Rates of suicide attempts and completion are similar with the use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.

Jul 1, 2015 Issue
NSAID Use Associated with Increased Risk of Serious Bleeding and CV Events After MI [POEMs]

The use of concomitant NSAIDs in adults who receive antithrombotic therapy after MI increases the risk of serious bleeding complications and recurrent adverse CV events. This study found the highest risk among users of celecoxib (Celebrex) and diclofenac, and the lowest risk among users of ibuprofen...

Jun 15, 2015 Issue
Amoxiclav Causes Diarrhea in 1 of 8 Persons Who Take It [POEMs]

The risk of diarrhea is significantly higher with amoxicillin/clavulanate (amoxiclav; Augmentin) than placebo, with a number needed to treat to harm (NNTH) of 8, which is not dissimilar from the number needed to treat for conditions such as otitis media. Contrary to popular belief, the risks of naus...

Feb 1, 2015 Issue
Benzodiazepines and Alzheimer Disease [AFP Journal Club]

Benzodiazepine exposure over the preceding five years seems to be associated with an increased likelihood of an Alzheimer disease diagnosis. A dose-response gradient also seems to exist.

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