ITEMS IN AFP WITH KEYWORD:
Drug Adverse Effects
This study found that maternal antidepressant use during the first trimester of pregnancy is associated with an increased risk of preterm birth, but not SGA, ASD, or ADHD. Another study in the same issue also reported no increased risk of ASD with in utero exposure to selective serotonin reuptake in...
A woman with a long history of cocaine use presented to the emergency department with leg ulcers and ecchymoses on her ears.
For some drugs, risk mitigation measures beyond FDA-approved labeling are deemed necessary. Learn more about these Risk Evaluation and Mitigation Strategies (REMS).
A man presented with asymptomatic blue-gray lesions on both feet that were darkening over time. He was using several medications.
Mirtazapine (Remeron) and venlafaxine are associated with higher rates of completed suicide in primary care patients. Rates of suicide attempts and completion are similar with the use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.
The use of concomitant NSAIDs in adults who receive antithrombotic therapy after MI increases the risk of serious bleeding complications and recurrent adverse CV events. This study found the highest risk among users of celecoxib (Celebrex) and diclofenac, and the lowest risk among users of ibuprofen...
The risk of diarrhea is significantly higher with amoxicillin/clavulanate (amoxiclav; Augmentin) than placebo, with a number needed to treat to harm (NNTH) of 8, which is not dissimilar from the number needed to treat for conditions such as otitis media. Contrary to popular belief, the risks of naus...
Benzodiazepine exposure over the preceding five years seems to be associated with an increased likelihood of an Alzheimer disease diagnosis. A dose-response gradient also seems to exist.
A woman taking an antibiotic presented with fever, blistering on her lips, and progressive sloughing of skin. She also had diffuse muscle aches and increased pigmentation and edema on her face. Laboratory tests revealed new acute renal insufficiency.
Mar 15, 2014 Issue
PPIs, Childhood Asthma, and the Problem of Therapeutic Creep [AFP Journal Club]
The use of a therapy in patients one would intuitively think might benefit, but in whom no benefit has been documented, is called therapeutic creep. The use of proton pump inhibitors for poorly controlled asthma is an example of this phenomenon.