Drug Adverse Effects

Feb 1, 2010 Issue
Boxed Warnings and Other FDA Communication Tools [Editorials]

Dec 15, 2009 Issue
NSAIDs and Cardiovascular Risk [Editorials]

Dec 15, 2009 Issue
NSAID Prescribing Precautions [Article]

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used, but have risks associated with their use, including significant upper gastrointestinal tract bleeding. Older persons, persons taking anticoagulants, and persons with a history of upper gastrointestinal tract bleeding associated with NS...

Oct 1, 2009 Issue
Gadolinium-Associated Nephrogenic Systemic Fibrosis [Article]

Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging. Because of this relationship between nephrogenic systemic fibrosis and ...

Dec 1, 2008 Issue
Facial Hyperpigmentation [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

Sep 15, 2008 Issue
Drug-Induced Nephrotoxicity [Article]

Drugs are a common source of acute kidney injury. Compared with 30 years ago, the average patient today is older, has more comorbidities, and is exposed to more diagnostic and therapeutic procedures with the potential to harm kidney function. Drugs shown to cause nephrotoxicity exert their toxic eff...

May 15, 2008 Issue
ACEP Policy on N-acetylcysteine for Acetaminophen Overdose [Practice Guidelines]

A subcommittee of the American College of Emergency Physicians (ACEP) has released a policy regarding indications for N-acetylcysteine in patients with acetaminophen overdose who can be risk stratified by the Rumack-Matthew nomogram, and for those who cannot.

Dec 15, 2007 Issue
Minimizing Adverse Drug Events in Older Patients [Article]

Adverse drug events are common in older patients, particularly in those taking at least five medications, but such events are predictable and often preventable. A rational approach to prescribing in older adults integrates physiologic changes of aging with knowledge of pharmacology. Focusing on spec...

Sep 15, 2007 Issue
AHA Releases Statement on the Use of COX-2 Inhibitors and NSAIDs [Practice Guidelines]

Physicians should consider the increased risks associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors, according to new guidelines issued by the American Heart Association (AHA).

Aug 1, 2007 Issue
The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects [Article]

Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...

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