ITEMS IN AFP WITH KEYWORD:
Drug Adverse Effects
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...
Jul 15, 2007 Issue
CDC Publishes Statement on Cough and Cold Medications in Children [Practice Guidelines]
The Centers for Disease Control and Prevention (CDC) has released a statement on the risks of cough and cold medications in children younger than two years. Health care professionals also should be aware of the risks of serious illness or fatal overdose.
Opioid analgesics are useful agents for treating pain of various etiologies; however, adverse effects are potential limitations to their use. Strategies to minimize adverse effects of opioids include dose reduction, symptomatic management, opioid rotation, and changing the route of administration. N...
Oct 1, 2006 Issue
ACOG Releases Guideline on Tamoxifen for Postmenopausal Women [Practice Guidelines]
The American College of Obstetricians and Gynecologists (ACOG) Committee on Gynecologic Practice has reviewed the risks of tamoxifen in postmenopausal women and released recommendations on its use in this population.
Photo Quiz presents readers with a clinical challenge based on a photograph or other image.
The U.S. Food and Drug Administration (FDA) has approved new label information for erectile dysfunction drugs after reports of sudden vision loss attributed to nonarteritic ischemic optic neuropathy. These drugs include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).
Jun 1, 2005 Issue
FDA Warns Against Off-Label Use of Antipsychotic Drugs [Practice Guidelines]
Drug hypersensitivity results from interactions between a pharmacologic agent and the human immune system. These types of reactions constitute only a small subset of all adverse drug reactions. Allergic reactions to medications represent a specific class of drug hypersensitivity reactions mediated b...
Older Americans comprise 13 percent of the population, but they consume an average of 30 percent of all prescription drugs. Every day, physicians are faced with issues surrounding appropriate prescribing to older patients. Polypharmacy, use of supplements, adherence issues, and the potential for adv...
Adverse reactions to contrast agents range from a mild inconvenience, such as itching associated with hives, to a life-threatening emergency. Renal toxicity is a well known adverse reaction associated with the use of intravenous contrast material. Other forms of adverse reactions include delayed all...