ITEMS IN AFP WITH KEYWORD:
Drug Adverse Effects
Drugs are a common source of acute kidney injury. Compared with 30 years ago, the average patient today is older, has more comorbidities, and is exposed to more diagnostic and therapeutic procedures with the potential to harm kidney function. Drugs shown to cause nephrotoxicity exert their toxic eff...
May 15, 2008 Issue
ACEP Policy on N-acetylcysteine for Acetaminophen Overdose [Practice Guidelines]
A subcommittee of the American College of Emergency Physicians (ACEP) has released a policy regarding indications for N-acetylcysteine in patients with acetaminophen overdose who can be risk stratified by the Rumack-Matthew nomogram, and for those who cannot.
Adverse drug events are common in older patients, particularly in those taking at least five medications, but such events are predictable and often preventable. A rational approach to prescribing in older adults integrates physiologic changes of aging with knowledge of pharmacology. Focusing on spec...
Sep 15, 2007 Issue
AHA Releases Statement on the Use of COX-2 Inhibitors and NSAIDs [Practice Guidelines]
Physicians should consider the increased risks associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors, according to new guidelines issued by the American Heart Association (AHA).
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...
Jul 15, 2007 Issue
CDC Publishes Statement on Cough and Cold Medications in Children [Practice Guidelines]
The Centers for Disease Control and Prevention (CDC) has released a statement on the risks of cough and cold medications in children younger than two years. Health care professionals also should be aware of the risks of serious illness or fatal overdose.
Opioid analgesics are useful agents for treating pain of various etiologies; however, adverse effects are potential limitations to their use. Strategies to minimize adverse effects of opioids include dose reduction, symptomatic management, opioid rotation, and changing the route of administration. N...
Oct 1, 2006 Issue
ACOG Releases Guideline on Tamoxifen for Postmenopausal Women [Practice Guidelines]
The American College of Obstetricians and Gynecologists (ACOG) Committee on Gynecologic Practice has reviewed the risks of tamoxifen in postmenopausal women and released recommendations on its use in this population.
Photo Quiz presents readers with a clinical challenge based on a photograph or other image.
The U.S. Food and Drug Administration (FDA) has approved new label information for erectile dysfunction drugs after reports of sudden vision loss attributed to nonarteritic ischemic optic neuropathy. These drugs include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra).