Drug Interactions

Jul 1, 2019 Issue
Polypharmacy: Evaluating Risks and Deprescribing [Article]

Polypharmacy, commonly defined as the use of at least five medications, can have negative consequences for both the patient and health care system. Physicians should identify and prioritize medications to discontinue and discuss potential deprescribing with patients. A specific follow-up plan should be developed, including reviewing the patient’s medication list at every visit.

May 1, 2019 Issue
Clinically Relevant Drug-Drug Interactions in Primary Care [Article]

The indentification of drug-drug interactions, which are common, is essential to patient safety. Minimizing drugs prescribed, evaluating drug therapy, nonpharmacologic options, monitoring for signs of toxicity or effectiveness, and adjusting dosages and times of dosages are ways to lessen interactions. Pharmacist consultation should be considered when medications with interaction potential must be prescribed.

Jul 15, 2017 Issue
Common Herbal Dietary Supplement—Drug Interactions [Article]

Which dietary supplements are safe to use with over-the-counter and prescription medications? Review a list of common supplements and potential drug interactions.

Jan 1, 2014 Issue
Inheriting Patients with Questionable Medication Regimens [Curbside Consultation]

Inheriting a patient on an inappropriate or questionable medical regimen is a scenario that every physician confronts when practicing continuity care. It can present frustrating challenges, especially for resident physicians, who, because of the nature of training programs, care for patient panels w...

Jan 1, 2008 Issue
Herbal and Dietary Supplement-Drug Interactions in Patients with Chronic Illnesses [Article]

Herbs and other dietary supplements may alter the actions of prescription and nonprescription drugs. Harmful effects are most pronounced with anticoagulants, cardiovascular medications, oral hypoglycemics, and antiretrovirals. Physicians should routinely ask patients about their use of dietary supplements and provide information about the safety and effectiveness of these products.

Aug 1, 2007 Issue
The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects [Article]

Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...

Aug 15, 2006 Issue
Management of Grapefruit-Drug Interactions [Article]

Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through th...

Mar 15, 2000 Issue
Clinically Significant Drug Interactions [Article]

A large number of drugs are introduced every year, and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions. Multiple drug regimens carry the risk of adverse interactions. P...

Mar 1, 1999 Issue
Herbal Remedies: Adverse Effects and Drug Interactions [Article]

A growing number of Americans are using herbal products for preventive and therapeutic purposes. The manufacturers of these products are not required to submit proof of safety and efficacy to the U.S. Food and Drug Administration before marketing. For this reason, the adverse effects and drug intera...

Jan 1, 1998 Issue
Cytochrome P450: New Nomenclature and Clinical Implications [Article]

Many drug interactions are a result of inhibition or induction of cytochrome P450 enzymes (CYP450). The CYP3A subfamily is involved in many clinically significant drug interactions, including those involving nonsedating antihistamines and cisapride, that may result in cardiac dysrhythmias. CYP3A4 an...

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