Drug Therapy

Nov 15, 1998 Issue
Aminoglycosides: A Practical Review [Article]

Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms. Gentamicin is the most commonly used am...

Oct 15, 1998 Issue
Appropriate Use of Antibiotics for URIs in Children: Part II. Cough, Pharyngitis and the Common Cold [Article]

This article summarizes the principles of judicious antimicrobial therapy for three of the five conditions--cough, pharyngitis, the common cold--that account for most of the outpatient use of these drugs in the United States. The principles governing the other two conditions, otitis media and acute ...

Oct 1, 1998 Issue
Appropriate Use of Antibiotics for URIs in Children: Part I. Otitis Media and Acute Sinusitis [Article]

Five conditions--otitis media, acute sinusitis, cough, pharyngitis and the common cold--account for most of the outpatient use of antibiotics in the United States. The first part of this two-part article presents guidelines that encourage physicians to make an appropriate distinction between acute o...

Aug 01, 1998 Issue
A Different Look at Corticosteroids [Article]

Systemic corticosteroids have been used in the treatment of numerous medical conditions for approximately 50 years. Short-acting products such as hydrocortisone are the least potent. Prednisone and methylprednisolone, which are intermediate-acting products, are four to five times more potent than hy...

May 1, 1998 Issue
Prescription to Over-the-Counter Drug Reclassification [Article]

Self-care is becoming increasingly popular among health care consumers. The availability of over-the-counter medications makes it possible for consumers to treat numerous ailments without the supervision of a health care professional. Many of the medications now available without a prescription were...

Mar 1, 1998 Issue
Antiviral Drugs in Healthy Children [Article]

Several antiviral agents are available to treat viral illnesses in healthy children. In some children, treatment with acyclovir is an alternative to vaccination for the treatment and prevention of chickenpox. Acyclovir also can be useful in the treatment or prevention of herpes simplex infections in...

Jan 1, 1998 Issue
Cytochrome P450: New Nomenclature and Clinical Implications [Article]

Many drug interactions are a result of inhibition or induction of cytochrome P450 enzymes (CYP450). The CYP3A subfamily is involved in many clinically significant drug interactions, including those involving nonsedating antihistamines and cisapride, that may result in cardiac dysrhythmias. CYP3A4 an...

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