Drug Therapy

Oct 15, 2016 Issue
All Analgesics Are Better Than Placebo in Patients with Knee or Hip DJD [POEMs]

In patients with hip or knee DJD, all analgesics are more effective than placebo in relieving pain and improving function. Although paracetamol (acetaminophen) is the least effective of all the drugs studied, it still may be the first treatment for these patients because of its safety profile.

Oct 15, 2016 Issue
Procalcitonin Guidance Safely Decreases Antibiotic Use in Critically Ill Patients [POEMs]

For patients in the intensive care unit (ICU) who receive antibiotics for presumed or proven bacterial infections, the use of procalcitonin levels to determine when to stop antibiotic therapy results in decreased duration and consumption of antibiotics without increasing mortality.

Oct 15, 2016 Issue
Low-Dose Morphine Less Effective Than Diclofenac or Acetaminophen for Renal Colic [POEMs]

This is a good example of how a well-done study can lead to erroneous conclusions. The comparator most likely to be effective here—titrated morphine—was used at a low dose and found to be less effective than intramuscular diclofenac or intravenous paracetamol (acetaminophen).

Oct 15, 2016 Issue
ACE Inhibitors or ARBs to Prevent CKD in Patients with Microalbuminuria [FPIN's Clinical Inquiries]

ACE inhibitors reduce the risk of progression to macroalbuminuria in normotensive patients with microalbuminuria and type 1 diabetes mellitus.

Oct 1, 2016 Issue
Rivaroxaban vs. Warfarin for Anticoagulation in Patients with Atrial Fibrillation Undergoing Ablation and Cardioversion [Medicine by the Numbers]

Studies showed that 433 patients needed to be treated with rivaroxaban to prevent one stroke and 629 patients needed to be treated with rivaroxaban to prevent one thromboembolic event. Read more.

Sep 15, 2016 Issue
Medications for Chronic Asthma [Article]

Therapeutic agents used in the management of chronic asthma aim to prevent symptoms by controlling airway inflammation and hyperreactivity. Medication regimens are organized in stepwise approaches based on patient age. Data regarding the safety and efficacy of popular complementary and alternative asthma treatments are largely unavailable.

Sep 1, 2016 Issue
Family Physicians Are Well Suited to Prescribe Isotretinoin [Editorials]

A few minutes (and a few clicks on the computer) can open up rewarding therapeutic opportunities when registering with iPledge to prescribe isotretinoin.

Aug 15, 2016 Issue
Behavioral Disorders in Dementia: Appropriate Nondrug Interventions and Antipsychotic Use [Article]

Find out which nonpharmacologic treatments are most effective, when antipsychotic therapy is indicated, which medications are appropriate in patients with comorbid conditions, and when antipsychotic therapy should be discontinued.

Jul 1, 2016 Issue
Procalcitonin-Guided Antibiotic Therapy for Acute Respiratory Infections [FPIN's Clinical Inquiries]

A procalcitonin-guided antibiotic therapy algorithm should be used to decrease antibiotic use in adults with acute respiratory infections. The use of a procalcitonin-guided therapy algorithm reduces antibiotic use by 3.47 days without increasing morbidity or mortality in adults with acute respiratory infections.

Jul 1, 2016 Issue
FDA Implements New Labeling for Medications Used During Pregnancy and Lactation [Editorials]

Deciding which medications to take during pregnancy and lactation can be a complex and individualized decision that should be discussed with a physician. The new PLLR can help remove some of the uncertainty clinicians and patients face by replacing the potentially confusing letter categories with a narrative structure.

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