Drug Therapy

Sep 1, 2014 Issue
ACE Inhibitors Decrease Cardiovascular Events in Patients with Diabetes, ARBs Do Not [POEMs]

In patients with diabetes, ACE inhibitors decrease cardiovascular events and all-cause mortality. ARBs do not. Both drug classes decrease heart failure incidence. Although both drug classes have been available for almost 15 years, there is only one study of 250 patients that directly compared their ...

Aug 15, 2014 Issue
2013 ACC/AHA Cholesterol Guideline Greatly Increases Number Eligible for Statin Treatment [POEMs]

The new guideline from the ACC/AHA increases the number of adults between 40 and 75 years of age who are eligible to take statins by 12.8 million. The largest increases were among adults who would take statins for primary prevention and for adults between 60 and 75 years of age. The authors estimate...

Jan 1, 2014 Issue
Staying on Track When Prescribing Off-Label [Editorials]

Off-label use of medications is common, accounting for approximately 10% to 20% of prescriptions. Physicians must evaluate the scientific evidence and use their best judgment to balance effectiveness and safety when choosing a medication for an individual patient.

Aug 15, 2013 Issue
Risks Associated with Long-Term Benzodiazepine Use [Editorials]

Many patients underestimate the degree of impairment caused by benzodiazepines. Benzodiazepines increase the risk of addiction, withdrawal, cognitive decline, motor vehicle crashes, and hip fracture. The risk of overdose is particularly great when combined with sedative drugs such as opioids or alcohol.

Feb 15, 2013 Issue
Pharmacologic Therapy for Vitamin D Deficiency [FPIN's Clinical Inquiries]

Cholecalciferol (vitamin D3) supplementation should be used for vitamin D repletion because it may be more effective in preventing nonvertebral fractures.

Nov 1, 2012 Issue
Antibiotic Use in Acute Upper Respiratory Tract Infections [Article]

Upper respiratory tract infections account for millions of visits to family physicians each year in the United States. Although warranted in some cases, antibiotics are greatly overused. This article outlines the guidelines and indications for appropriate antibiotic use for common upper respiratory ...

Mar 15, 2012 Issue
Medications for Weight Loss in Patients with Type 2 Diabetes Mellitus [FPIN's Clinical Inquiries]

Fluoxetine (Prozac) and orlistat (Xenical) produce modest short-term weight loss, but their long-term benefits are unclear and their safety is uncertain.

Oct 1, 2011 Issue
Improving Medication Adherence in Patients with Comorbidities [FPIN's Clinical Inquiries]

Interventions that involve pharmacists to review, simplify, and monitor medication use significantly improve adherence in patients with multiple medical conditions.

Apr 1, 2011 Issue
Appetite Suppressants as Adjuncts for Weight Loss [FPIN's Clinical Inquiries]

Phentermine and diethylpropion are appetite suppressants approved for use in the United States as adjuncts in the treatment of obesity. These agents demonstrate a modest weight loss benefit when combined with dietary modifications and exercise.

Mar 15, 2011 Issue
Antibiotics for Viral Upper Respiratory Tract Infections in Children [FPIN's Clinical Inquiries]

Antibiotic therapy does not benefit children with bronchiolitis, the common cold, or nonstreptococcal pharyngitis. If purulent rhinitis is present for more than 10 days, antibiotics shorten the duration of runny nose symptoms.

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