ITEMS IN AFP WITH KEYWORD:
Dec 15, 2010 Issue
Thiazolidinedione Therapy for Managing Metabolic Syndrome [FPIN's Clinical Inquiries]
There is no patient-oriented evidence supporting the use of TZD therapy in patients in the general population who have metabolic syndrome. Rosiglitazone (Avandia) use decreases cardiovascular morbidity and mortality in patients with metabolic syndrome who are undergoing coronary stenting.
Our society values brand-name products, and drugs are no exception. However, only rudimentary safety information is available for new drugs. Required safety studies are short-term and may involve only 100 to 300 patients. Randomized controlled trials, the gold standard for testing effectiveness, may also be short-term.
At the time of launch, a new drug usually has not been as widely tested as other available therapies, and there is often insufficient good-quality published evidence to adequately judge its true effectiveness and safety. A careful and critical approach to the assessment and prescription of new drugs is needed to ensure their use is appropriate.
Boxed warnings, commonly referred to as 'black box' warnings, are issued by the U.S. Food and Drug Administration and featured in the labeling of drugs associated with serious adverse reactions. These safety concerns are typically identified through the Adverse Event Reporting System and the Office ...
Physiologic differences between men and women affect drug activity, including pharmacokinetics and pharmacodynamics. Pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate. Because of del...
What are the effects of providing sample medications to patients? It increases prescription costs and causes physicians to use second-line choices.
Topical corticosteroids are one of the oldest and most useful treatments for dermatologic conditions. There are many topical steroids available, and they differ in potency and formulation. Successful treatment depends on an accurate diagnosis and consideration of the steroid's delivery vehicle, pote...