Drug Therapy

Feb 1, 2010 Issue
FDA Boxed Warnings: How to Prescribe Drugs Safely [Article]

Boxed warnings, commonly referred to as 'black box' warnings, are issued by the U.S. Food and Drug Administration and featured in the labeling of drugs associated with serious adverse reactions. These safety concerns are typically identified through the Adverse Event Reporting System and the Office ...

Jan 15, 2010 Issue
Drug Pricing in AFP--How Much Does a Drug Cost? [Editorials]

Dec 1, 2009 Issue
Sex-Based Differences in Drug Activity [Article]

Physiologic differences between men and women affect drug activity, including pharmacokinetics and pharmacodynamics. Pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate. Because of del...

Oct 1, 2009 Issue
Drug Information Services: The Answer to Your Drug-Related Questions [Editorials]

May 15, 2009 Issue
Sample Medications and Overall Prescription Costs [AFP Journal Club]

What are the effects of providing sample medications to patients? It increases prescription costs and causes physicians to use second-line choices.

Jan 15, 2009 Issue
Choosing Topical Corticosteroids [Article]

Topical corticosteroids are one of the oldest and most useful treatments for dermatologic conditions. There are many topical steroids available, and they differ in potency and formulation. Successful treatment depends on an accurate diagnosis and consideration of the steroid's delivery vehicle, pote...

Aug 1, 2008 Issue
Choosing a Skeletal Muscle Relaxant [Article]

Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs f...

Jun 1, 2008 Issue
Genetic Factors In Drug Metabolism [Article]

Patients vary widely in their response to drugs. Having an understanding of the pharmacokinetic and pharmacodynamic properties of various medications is importantwhen assessing ethnic differences in drug response. Genetic factors can account for 20 to 95 percent of patient variability. Genetic polym...

Oct 15, 2007 Issue
Pharmacogenentics: Using DNA to Optimize Drug Therapy [Article]

Pharmacogenetics is a growing field of research that focuses on the interaction between genetics and drug therapy. Relationships between genetic variation and drug effect have been observed for a growing number of commonly used drugs. Validation studies may soon define the use of these relationships...

Aug 1, 2007 Issue
The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects [Article]

Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...

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