Drug Therapy

Dec 15, 2010 Issue
Thiazolidinedione Therapy for Managing Metabolic Syndrome [FPIN's Clinical Inquiries]

There is no patient-oriented evidence supporting the use of TZD therapy in patients in the general population who have metabolic syndrome. Rosiglitazone (Avandia) use decreases cardiovascular morbidity and mortality in patients with metabolic syndrome who are undergoing coronary stenting.

Jul 1, 2010 Issue
Prescribing Evidence: The Effectiveness and Safety of New Drugs [Editorials]

Our society values brand-name products, and drugs are no exception. However, only rudimentary safety information is available for new drugs. Required safety studies are short-term and may involve only 100 to 300 patients. Randomized controlled trials, the gold standard for testing effectiveness, may also be short-term.

Jul 1, 2010 Issue
Evaluating the Safety and Effectiveness of New Drugs [Article]

At the time of launch, a new drug usually has not been as widely tested as other available therapies, and there is often insufficient good-quality published evidence to adequately judge its true effectiveness and safety. A careful and critical approach to the assessment and prescription of new drugs is needed to ensure their use is appropriate.

Mar 1, 2010 Issue
Use of Atypical Antipsychotics in Children: Balancing Safety and Effectiveness [Editorials]

Feb 1, 2010 Issue
FDA Boxed Warnings: How to Prescribe Drugs Safely [Article]

Boxed warnings, commonly referred to as 'black box' warnings, are issued by the U.S. Food and Drug Administration and featured in the labeling of drugs associated with serious adverse reactions. These safety concerns are typically identified through the Adverse Event Reporting System and the Office ...

Jan 15, 2010 Issue
Drug Pricing in AFP--How Much Does a Drug Cost? [Editorials]

Dec 1, 2009 Issue
Sex-Based Differences in Drug Activity [Article]

Physiologic differences between men and women affect drug activity, including pharmacokinetics and pharmacodynamics. Pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate. Because of del...

Oct 1, 2009 Issue
Drug Information Services: The Answer to Your Drug-Related Questions [Editorials]

May 15, 2009 Issue
Sample Medications and Overall Prescription Costs [AFP Journal Club]

What are the effects of providing sample medications to patients? It increases prescription costs and causes physicians to use second-line choices.

Jan 15, 2009 Issue
Choosing Topical Corticosteroids [Article]

Topical corticosteroids are one of the oldest and most useful treatments for dermatologic conditions. There are many topical steroids available, and they differ in potency and formulation. Successful treatment depends on an accurate diagnosis and consideration of the steroid's delivery vehicle, pote...

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