Drug Therapy

Oct 15, 2007 Issue
Pharmacogenentics: Using DNA to Optimize Drug Therapy [Article]

Pharmacogenetics is a growing field of research that focuses on the interaction between genetics and drug therapy. Relationships between genetic variation and drug effect have been observed for a growing number of commonly used drugs. Validation studies may soon define the use of these relationships...

Aug 1, 2007 Issue
The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects [Article]

Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a p...

Jul 1, 2007 Issue
Preventing Premature Discontinuation of Thienopyridine Therapy [Practice Guidelines]

Thienopyridine therapy is recommended by the American Heart Association (AHA) and the American College of Cardiology (ACC) for patients who are undergoing percutaneous coronary intervention. Prematurely discontinuing antiplatelet therapy increases the risk of stent thrombosis, which often leads to acute myocardial infarction or death.

Jan 15, 2007 Issue
Appropriate Prescribing of Medications: An Eight-Step Approach [Article]

A systematic approach advocated by the World Health Organization can help minimize poor-quality and erroneous prescribing. This six-step approach to prescribing suggests that the physician should (1) evaluate and dearly define the patient's problem; (2) specify the therapeutic objective; (3) select ...

Sep 15, 2006 Issue
Guidelines for the Use of Antibiotics in Acute Upper Respiratory Infections [Article]

To help physicians with the appropriate use of antibiotics in children and adults with upper respiratory tract infection, a multidisciplinary team evaluated existing guidelines and summarized key practice points. Acute otitis media in children should be diagnosed only if there is abrupt onset, signs...

Sep 1, 2006 Issue
Promoting Medication Adherence in Children [Article]

The problem of getting children to follow a treatment regimen is widespread and is frustrating for physicians. The extent to which any patient adheres to a medical regimen is an essential determinant of clinical success. Strategies to improve adherence in children include using simplified drug regim...

Jul 15, 2006 Issue
CDC Releases Guidelines on Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis [Practice Guidelines]

The Centers for Disease Control and Prevention (CDC) has released guidelines on antimicrobial agents for the treatment and postexposure prophylaxis of pertussis.

May 1, 2006 Issue
Testosterone Treatments: Why, When, and How? [Article]

Testosterone treatment is controversial for men and even more so for women. Although long-term outcome data are not available, prescriptions for testosterone are becoming more common. Testosterone is used primarily to treat symptoms of sexual dysfunction in men and women and hot flashes in women. Po...

Feb 1, 2006 Issue
Nonsteroidal Anti-inflammatory Drugs [Clinical Evidence Handbook]

Are there any important differences between available nonsteroidal anti-inflammatory drugs (NSAIDs)? What are the effects of cotreatments on reducing the risk of the adverse gastrointestinal effects of NSAIDs? What are the effects of topical NSAIDs?

Jun 1, 2005 Issue
Other FDA Advisories [Practice Guidelines]

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