Gastroesophageal Reflux Disease

May 15, 2010 Issue
Diagnosis of Gastroesophageal Reflux Disease [Point-of-Care Guides]

Diagnosis of GERD may be clinical (presentation with typical symptoms, such as heartburn); physiologic (evidence of abnormal pH levels in the distal esophagus); anatomic (evidence of esophagitis on endoscopy); or functional (clinical response to antacid medications). However, the correlation between these diagnostic approaches is relatively poor.

Jan 15, 2009 Issue
GERD in Adults [Clinical Evidence Handbook]

What are the effects of initial and maintenance treatment of GERD associated with esophagitis?

Aug 15, 2008 Issue
Atypical Presentations of Gastroesophageal Reflux Disease [Article]

Gastroesophageal reflux disease typically manifests as heartburn and regurgitation, but it may also present with atypical or extraesophageal symptoms, including asthma, chronic cough, laryngitis, hoarseness, chronic sore throat, dental erosions, and noncardiac chest pain. Diagnosing atypical manifes...

Mar 1, 2008 Issue
Medical Treatments in the Short-term Management of Reflux Esophagitis [Cochrane for Clinicians]

Proton pump inhibitors (PPIs) are the most effective short-term treatment for reflux esophagitis. Histamine H2 blockers are also effective compared with placebo, but are inferior to PPIs. There is limited evidence about adverse events with these therapies, but long-term therapy with PPIs has been shown to increase hip fracture risk.

Nov 1, 2007 Issue
Choosing One PPI Treatment Over Another [AFP Journal Club]

Is one PPI better than another? All PPIs are equally effective in equipotent dosages, and choice should be based on price.

Jun 15, 2005 Issue
Updated ACG Guidelines for Diagnosis and Treatment of GERD [Practice Guidelines]

The American College of Gastroenterology (ACG) has updated its guidelines for the diagnosis and treatment of gastroesophageal reflux disease (GERD) to reflect the continuing advances in this area.

Jun 1, 2005 Issue
Treating GER in Children Younger Than Two Years [Cochrane for Clinicians]

Thickened feeds and metoclopramide reduce symptoms of GER in normally developing infants. However, elevating the head of the crib appears to have no effect.

Apr 1, 2005 Issue
Comparison of Short-Term Treatments for GERD [Cochrane for Clinicians]

For empiric treatment of GERD or endoscopy-negative reflux disease, a short trial of a proton pump inhibitor increases the chance of remission. Histamine H2-receptor antagonists are less expensive and work well in many patients, particularly those with less severe symptoms or endoscopy-negative reflux disease.

Oct 1, 2003 Issue
Management of Gastroesophageal Reflux Disease [Article]

The primary treatment goals in patients with gastroesophageal reflux disease are relief of symptoms, prevention of symptom relapse, healing of erosive esophagitis, and prevention of complications of esophagitis. In patients with reflux esophagitis, treatment is directed at acid suppression through t...

Sep 15, 2003 Issue
Evaluation of Epigastric Discomfort and Management of Dyspepsia and GERD [Practice Guidelines]

The Institute for Clinical Systems Improvement (ICSI) recently published a guideline on the evaluation and management of dyspepsia and gastroesophageal reflux disease (GERD).

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