Mar 15, 2018 Issue
Lesinurad (Zurampic) for Gout [STEPS]

Lesinurad taken in addition to a xanthine oxidase inhibitor reduces serum uric acid levels. However, it does not reduce the likelihood of experiencing a gout flare-up or completely resolving tophi.

Dec 1, 2017 Issue
Acute Gout: ACP Provides Guideline on Diagnosis [Practice Guidelines]

The diagnostic standard for acute gout is joint aspiration with synovial fluid analysis for monosodium urate crystals; however, many patients are seen in a primary care or emergency medicine situation where synovial fluid analysis is rarely performed. The American College of Physicians (ACP) has dev...

Nov 15, 2017 Issue
Gout: Diagnosis and Management [Implementing AHRQ Effective Health Care Reviews]

What is the accuracy of clinical decision tools and imaging for the diagnosis of gout in the primary care setting, and how effective are medications used to treat and prevent gout?

Sep 15, 2016 Issue
Clinical Diagnosis of Gout Without Joint Aspirate [Point-of-Care Guides]

Gout is ideally diagnosed through identification of characteristic negatively birefringent crystals under polarized light microscopy in fluid aspirated from end-organ deposits, typically from a joint. However, fewer than 10% of patients with gout see a rheumatologist, and most cases of gout are diag...

Oct 1, 2015 Issue
Risk of Gout with the Use of Thiazide Diuretics [FPIN's Clinical Inquiries]

Thiazide diuretics may be used in most patients with hypertension who have only minimally increased risk of gout.

Jun 1, 2015 Issue
Colchicine for Acute Gout [Cochrane for Clinicians]

Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout.

Dec 15, 2014 Issue
Diagnosis, Treatment, and Prevention of Gout [Article]

Find out whether newer medications are any more effective than older ones, and the latest evidence on dietary modifications and pharmacologic therapy for prevention of recurrent gout.

Mar 1, 2014 Issue
Joint Pain and Swelling [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

Sep 15, 2013 Issue
ACR Publishes Guidelines for Pharmacologic and Nonpharmacologic Treatment of Gout [Practice Guidelines]

The American College of Rheumatology (ACR) has developed recommendations for the management of gout. The recommendations call for a systematic nonpharmacologic and pharmacologic management approach that is intended to be applicable to all patients with gout.

May 15, 2010 Issue
Febuxostat (Uloric) for Hyperuricemia and Gout [STEPS]

Febuxostat more effectively lowers serum uric acid to goal levels than does allopurinol; however, this benefit is offset by a slightly higher incidence of adverse effects and treatment discontinuation. Until superiority for patient-oriented outcomes is shown in comparative trials with allopurinol, f...

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