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Peptic ulcer disease is usually caused by Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs. Find out how to diagnose the cause, as well as the available treatment options.
Dec 1, 2014 Issue
Optimal Duration of Treatment Regimens for H. pylori Eradication [Cochrane for Clinicians]
When using proton pump inhibitor (PPI) triple therapy, increasing the duration of treatment from seven to 10 days or from 10 to 14 days significantly increases the eradication of H. pylori. When using other treatment regimens, it is unclear whether increasing duration of treatment changes eradication rates.
Peptic ulcer disease usually occurs in the stomach and proximal duodenum. The predominant causes in the United States are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs. Symptoms of peptic ulcer disease include epigastric discomfort (specifically, pain relieved by...
One half of the world's population has Helicobacter pylori infection, with an estimated prevalence of 30 percent in North America. Although it is unclear whether eradication of H. pylori improves symptoms in patients with nonulcer dyspepsia, there is strong evidence that eradication of this bacteria...
What are the effects of treatments?
Helicobacter pylori is the cause of most peptic ulcer disease and a primary risk factor for gastric cancer. Eradication of the organism results in ulcer healing and reduces the risk of ulcer recurrence and complications. Testing and treatment have no clear value in patients with documented nonulcer ...
Nov 1, 2001 Issue
Symptomatic Treatment and H. pylori Eradication Therapy for Nonulcer Dyspepsia [Cochrane for Clinicians]
Bismuth subcitrate, histamine H2-receptor antagonists or proton pump inhibitors could be recommended for short-term relief of symptoms. Eradication of H. pylori would slightly decrease this patient's chance of having persistent symptoms over the next three to 12 months.