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Sep 01, 2021 Issue
Comparison of Treatment Regimens for Helicobacter pylori Infection [Medicine by the Numbers]
A network meta-analysis found that vonoprazan-based triple therapy and reverse hybrid therapy demonstrated the highest overall cure rates and SUCRA values; however, among Western countries, levofloxacin-based triple therapy had the highest cure rate and SUCRA value. Standard triple therapy was the least effective regimen overall.
Jul 1, 2019 Issue
Noninvasive Diagnostic Tests for Helicobacter pylori Infection [Cochrane for Clinicians]
When compared with serology or stool antigen tests, the urea breath test has the highest diagnostic accuracy to identify H. pylori infection in patients without a history of gastrectomy or recent use of antibiotics or proton pump inhibitors.
Jun 15, 2019 Issue
H. pylori Screening Before Initiation of Long-term NSAIDs [FPIN's Clinical Inquiries]
Physicians should perform laboratory screening for and eradicate H. pylori before initiating long-term NSAID therapy in NSAID-naive patients to reduce the risk of peptic ulcer disease.
Jan 15, 2018 Issue
H. pylori Infection: ACG Updates Treatment Recommendations [Practice Guidelines]
Helicobacter pylori infection is one of the most common chronic bacterial infections. The American College of Gastroenterology (ACG) has updated its clinical guidelines in response to significant scientific advances in the management of this disease.
Peptic ulcer disease is usually caused by Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs. Find out how to diagnose the cause, as well as the available treatment options.
Dec 1, 2014 Issue
Optimal Duration of Treatment Regimens for H. pylori Eradication [Cochrane for Clinicians]
When using proton pump inhibitor (PPI) triple therapy, increasing the duration of treatment from seven to 10 days or from 10 to 14 days significantly increases the eradication of H. pylori. When using other treatment regimens, it is unclear whether increasing duration of treatment changes eradication rates.
Peptic ulcer disease usually occurs in the stomach and proximal duodenum. The predominant causes in the United States are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs. Symptoms of peptic ulcer disease include epigastric discomfort (specifically, pain relieved by...
One half of the world's population has Helicobacter pylori infection, with an estimated prevalence of 30 percent in North America. Although it is unclear whether eradication of H. pylori improves symptoms in patients with nonulcer dyspepsia, there is strong evidence that eradication of this bacteria...
What are the effects of treatments?
Helicobacter pylori is the cause of most peptic ulcer disease and a primary risk factor for gastric cancer. Eradication of the organism results in ulcer healing and reduces the risk of ulcer recurrence and complications. Testing and treatment have no clear value in patients with documented nonulcer ...