Heart Failure

Apr 15, 2016 Issue
Ivabradine (Corlanor) for Heart Failure [STEPS]

In patients with stable systolic heart failure already on maximal medication therapy, adding ivabradine may reduce the number of hospitalizations related to heart failure (NNT for two years = 20), but it does not reduce cardiovascular mortality. In addition, many patients will not tolerate the drug ...

Mar 1, 2016 Issue
Transitional Care Interventions to Prevent Readmissions for Patients with Heart Failure [Implementing AHRQ Effective Health Care Reviews]

Home visiting programs and multidisciplinary clinic interventions for adult patients with heart failure reduced all-cause readmissions and mortality over three to six months. Structured telephone support reduced heart failure–specific readmissions and mortality over three to six months. However, str...

Apr 1, 2015 Issue
Valsartan/Sacubitril Reduces Mortality More Than Enalapril 10 mg Twice Daily in Patients With Heart Failure [POEMs]

The combination of an angiotensin receptor blocker (valsartan) and neprilysin inhibitor (sacubitril) reduces cardiovascular mortality more than an angiotensin-converting enzyme (ACE) inhibitor (enalapril [Vasotec]) alone, with an acceptable safety and tolerability profile. The choice of dosage is co...

Feb 15, 2015 Issue
Diagnosing and Managing Acute Heart Failure Guidelines: NICE [POEMs]

There is not much new in these guidelines except some caveats on what not to do. Diagnose new acute heart failure with a natriuretic peptide measurement and, if the level is high, follow with transthoracic echocardiography. Do not routinely treat with opiates, nitrates, inotropes, vasopressors, or c...

Sep 1, 2014 Issue
ACE Inhibitors Decrease Cardiovascular Events in Patients with Diabetes, ARBs Do Not [POEMs]

In patients with diabetes, ACE inhibitors decrease cardiovascular events and all-cause mortality. ARBs do not. Both drug classes decrease heart failure incidence. Although both drug classes have been available for almost 15 years, there is only one study of 250 patients that directly compared their ...

Aug 1, 2014 Issue
ACCF and AHA Release Guidelines on the Management of Heart Failure [Practice Guidelines]

The American College of Cardiology Foundation (ACCF) and American Heart Association (AHA) recently developed guidelines on the diagnosis and treatment of heart failure. The guidelines are based on four progressive stages of heart failure; progression from one stage to the next is associated with red...

Apr 1, 2014 Issue
Sodium Restriction in Heart Failure: How Low Should You Go? [Editorials]

Several guidelines now recommend that patients with heart failure limit their sodium intake. Many physicians are unaware, however, that there is controversy about the degree to which they should encourage patients with heart failure to restrict their sodium intake.

Dec 1, 2013 Issue
Skip the Strict Salt and Fluid Restriction for Hospitalized Patients with Heart Failure [POEMs]

This study suggests that a low-sodium and fluid-restricted diet, compared with a non-restricted diet, for patients hospitalized with acute decompensated heart failure does not expedite weight loss or decrease congestion. Patients placed on such diets are, as expected, significantly thirstier than th...

Jul 15, 2012 Issue
Heart Failure [Clinical Evidence Handbook]

What are the effects of multidisciplinary interventions, exercise, and drug treatments for heart failure?

Jun 15, 2012 Issue
Diagnosis and Evaluation of Heart Failure [Article]

Heart failure is a common clinical syndrome characterized by dyspnea, fatigue, and signs of volume overload, which may include peripheral edema and pulmonary rales. Heart failure has high morbidity and mortality rates, especially in older persons. Many conditions, such as coronary artery disease, hy...

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