Hematologic Disorders

Sep 01, 2021 Issue
Hereditary Hemochromatosis: Rapid Evidence Review [Article]

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinic...

Sep 01, 2021 Issue
Splenomegaly: Diagnosis and Management in Adults [Article]

Splenomegaly can be due to several mechanisms but is almost always a sign of a systemic condition. Patient habits, travel, and medical conditions can increase risk of splenomegaly and suggest etiology. Symptoms can suggest infectious, malignant, hepatic, or hematologic causes. Physical examination w...

Jun 1, 2021 Issue
Polycythemia Vera: Rapid Evidence Review [Article]

Polycythemia vera is a common myeloproliferative neoplasm characterized by erythrocytosis, often with associated leukocytosis and thrombocytosis. It has a significant negative impact on overall mortality and morbidity in the form of arterial and venous clots, fatigue, pruritus, and conversion to leukemia and myelofibrosis. Major diagnostic criteria include elevated hemoglobin or hematocrit level, abnormal bone marrow biopsy, and presence of the Janus kinase 2 genetic mutation. First-line treatments, such as low-dose aspirin and goal-directed phlebotomy to a hematocrit level of less than 45% to reduce thrombotic events, improve quality of life, and prolong survival. When indicated, cytoreductive therapy, primarily with hydroxyurea, can be added with consideration of second-line agents, including pegylated interferon-alfa and busulfan. Smoking cessation and cardiometabolic disease are modifiable risk factors that should be addressed to reduce the risk of thrombosis.

Aug 1, 2019 Issue
Hematologic Abnormality in a Young Soldier [Photo Quiz]

Feb 15, 2016 Issue
Clinical Evaluation of Bleeding and Bruising in Primary Care [Article]

Find out what to look for in the patient history and physical examination, which medications can cause abnormal bleeding and bruising, how to interpret laboratory results, and when to refer patients to a hematologist.

Dec 1, 2015 Issue
Evaluation of Patients with Leukocytosis [Article]

Review the types of white blood cells, the most common malignant and nonmalignant causes of leukocytosis, and the key examination and laboratory findings to determine the etiology.

Mar 15, 2012 Issue
Thrombocytopenia [Article]

Thrombocytopenia is defined as a platelet count of less than 150 × 103 per µL. It is often discovered incidentally when obtaining a complete blood count during an office visit. The etiology usually is not obvious, and additional investigation is required. Patients with platelet counts greater than 5...

Dec 15, 2009 Issue
Nonhealing Diaper Rash with Associated Hepatosplenomegaly [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

Dec 1, 2009 Issue
Diagnosis and Management of Von Willebrand Disease: Guidelines for Primary Care [Article]

Von Willebrand disease is an inherited condition characterized by deficiency of von Willebrand factor, which is essential in hemostasis. The National Heart, Lung, and Blood Institute has released new evidence-based guidelines for the diagnosis and management of the disease. There are three major sub...

Aug 15, 2009 Issue
Alpha and Beta Thalassemia [Article]

The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin ...

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