Hematologic Disorders

Apr 01, 2022 Issue
Recurrent Venous Thromboembolism [Article]

Venous thromboembolism (VTE) recurrence rates are three times higher in patients with chronic or no risk factors compared with those who have transient risk factors after stopping anticoagulation therapy. In patients with unprovoked VTE, age-appropriate screening is sufficient evaluation for occult ...

Mar 01, 2022 Issue
Alpha- and Beta-thalassemia: Rapid Evidence Review [Article]

Thalassemia is a group of autosomal recessive hemoglobinopathies affecting the production of normal alpha- or beta-globin chains that comprise hemoglobin. Ineffective production of alpha- or beta-globin chains may result in ineffective erythropoiesis, premature red blood cell destruction, and anemia...

Sep 01, 2021 Issue
Hereditary Hemochromatosis: Rapid Evidence Review [Article]

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinic...

Sep 01, 2021 Issue
Splenomegaly: Diagnosis and Management in Adults [Article]

Splenomegaly can be due to several mechanisms but is almost always a sign of a systemic condition. Patient habits, travel, and medical conditions can increase risk of splenomegaly and suggest etiology. Symptoms can suggest infectious, malignant, hepatic, or hematologic causes. Physical examination w...

Jun 1, 2021 Issue
Polycythemia Vera: Rapid Evidence Review [Article]

Polycythemia vera is a common myeloproliferative neoplasm characterized by erythrocytosis, often with associated leukocytosis and thrombocytosis. It has a significant negative impact on overall mortality and morbidity in the form of arterial and venous clots, fatigue, pruritus, and conversion to leukemia and myelofibrosis. Major diagnostic criteria include elevated hemoglobin or hematocrit level, abnormal bone marrow biopsy, and presence of the Janus kinase 2 genetic mutation. First-line treatments, such as low-dose aspirin and goal-directed phlebotomy to a hematocrit level of less than 45% to reduce thrombotic events, improve quality of life, and prolong survival. When indicated, cytoreductive therapy, primarily with hydroxyurea, can be added with consideration of second-line agents, including pegylated interferon-alfa and busulfan. Smoking cessation and cardiometabolic disease are modifiable risk factors that should be addressed to reduce the risk of thrombosis.

Aug 1, 2019 Issue
Hematologic Abnormality in a Young Soldier [Photo Quiz]

Feb 15, 2016 Issue
Clinical Evaluation of Bleeding and Bruising in Primary Care [Article]

Find out what to look for in the patient history and physical examination, which medications can cause abnormal bleeding and bruising, how to interpret laboratory results, and when to refer patients to a hematologist.

Dec 1, 2015 Issue
Evaluation of Patients with Leukocytosis [Article]

Review the types of white blood cells, the most common malignant and nonmalignant causes of leukocytosis, and the key examination and laboratory findings to determine the etiology.

Mar 15, 2012 Issue
Thrombocytopenia [Article]

Thrombocytopenia is defined as a platelet count of less than 150 × 103 per µL. It is often discovered incidentally when obtaining a complete blood count during an office visit. The etiology usually is not obvious, and additional investigation is required. Patients with platelet counts greater than 5...

Dec 15, 2009 Issue
Nonhealing Diaper Rash with Associated Hepatosplenomegaly [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

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