ITEMS IN AFP WITH KEYWORD:
Icosapent ethyl is safe, well tolerated and effective in preventing ischemic events including stroke and heart attack.
Hypertriglyceridemia is associated with increased risk of cardiovascular disease, and severely elevated triglyceride levels increase the risk of pancreatitis. Common risk factors for hypertriglyceridemia include obesity, metabolic syndrome, and type 2 diabetes mellitus. Management starts with lifestyle modifications such as diet and exercise. Statins can be considered for patients with high triglyceride levels who have borderline or intermediate 10-year risk of atherosclerotic cardiovascular disease. Icosapent can be added in patients at high cardiovascular risk if triglyceride levels remain high despite statin use. Fibrates, omega-3 fatty acids, or niacin may be considered in patients with severe hypertriglyceridemia to reduce the risk of pancreatitis.
These updated guidelines, made without any input from primary care physicians who manage most patients with hyperlipidemia, are more complex than the 2013 guidelines and will likely lead to even more recommendations for statins, ezetimibe (Zetia), and PSK9 inhibitors.
The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol guideline.
These results confirm that the use of statins for men with an LDL cholesterol level of at least 190 mg per dL, regardless of calculated risk, is associated with a clinically and statistically significant reduction in cardiovascular events and probably cardiovascular and all-cause mortality.
Prescription niacin (nicotinic acid, vitamin B3) does not reduce myocardial infarctions, strokes, or overall mortality when used for primary or secondary prevention.
Dec 15, 2017 Issue
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults [Putting Prevention into Practice]
L.D., a 66-year-old generally healthy white man, presents for his annual physical. He has no history of cardiovascular disease (CVD); he has had consistent systolic blood pressure measurements of 140 mm Hg; he is not taking any medications; he does not smoke; he exercises three times per week; and his body mass index is 25 kg per m2.
Nov 1, 2017 Issue
Statins in Persons at Low Risk of Cardiovascular Disease [Medicine by the Numbers]
Despite the small reductions in nonfatal heart attacks and strokes, statins were not associated with a reduction in serious illness overall.
Oct 15, 2017 Issue
Screening for Lipid Disorders in Children and Adolescents [Putting Prevention into Practice]
A healthy 12-year-old boy presents for a school physical and well visit. His family history reveals that his maternal grandfather had a heart attack at 75 years of age and that his 52-year-old father has started taking a medication for elevated cholesterol levels.
Jan 15, 2017 Issue
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Recommendation Statement [U.S. Preventive Services Task Force]
The USPSTF recommends that adults without a history of cardiovascular disease (CVD) (i.e., symptomatic coronary artery disease or ischemic stroke) use a low- to moderate-dose statin for the prevention of CVD events and mortality when all of the following criteria are met: (1) they are aged 40 to 75 ...