Aug 15, 2014 Issue
Should Family Physicians Follow the New ACC/AHA Cholesterol Treatment Guideline? Not Completely: Why It Is Right to Drop LDL-C Targets but Wrong to Recommend Statins at a 7.5% 10-Year Risk [Editorials: Controversies in Family Medicine]

The recommendations should have paid more attention to the inherent uncertainties in risk estimates and the importance of individual patient circumstances and preferences.

Apr 15, 2014 Issue
Apolipoproteins for Cardiovascular Risk Assessment [FPIN's Clinical Inquiries]

Measurement of apolipoprotein B and apolipoprotein A-I is no better than traditional lipid measurements and should not be used to predict cardiovascular risk.

Feb 15, 2014 Issue
Fish Oil for Treatment of Dyslipidemia [FPIN's Clinical Inquiries]

Supplementation with omega-3 fatty acids decreases triglyceride and very low-density lipoprotein cholesterol levels. However, it can also increase low-density lipoprotein (LDL) cholesterol levels. Treatment with omega-3 fatty acids does not decrease total mortality, cardiovascular events, or cancer ...

Jul 15, 2013 Issue
Endocrine Society Releases Guidelines on Diagnosis and Management of Hypertriglyceridemia [Practice Guidelines]

The Endocrine Society recently published evidence-based recommendations on the diagnosis and management of hypertriglyceridemia in adults. Contributing factors include overweight and obesity, physical inactivity, excessive alcohol intake, metabolic syndrome, type 2 diabetes mellitus, and certain gen...

Oct 15, 2012 Issue
Should Family Physicians Routinely Screen for Hypercholesterolemia in Children? No: Universal Screening has Uncertain Benefits and a High Risk of Harms [Editorials: Controversies in Family Medicine]

No: Universal Screening Has Uncertain Benefits and a High Risk of Harms. Atherosclerosis can be demonstrated in young arteries, and its development over time correlates with the presence of risk factors for the disease, including higher lipid levels. But the presence of this association should not prompt screening just because it is available.

Oct 15, 2012 Issue
Should Family Physicians Routinely Screen for Hypercholesterolemia in Children? Yes: The Evidence Supports Universal Screening [Editorials: Controversies in Family Medicine]

Yes: The Evidence Supports Universal Screening. Atherosclerotic cardiovascular disease events are the culmination of a process that has clearly been shown to begin in childhood, with accumulation of abnormal lipids in the vascular intima.

Oct 1, 2011 Issue
Statins for Primary Cardiovascular Prevention [Cochrane for Clinicians]

Trials to date have found that statins reduce all-cause mortality, composite cardiovascular outcomes, and revascularization. However, most trials included large numbers of persons with known CVD. Clear evidence of the effectiveness of statins to prevent a first cardiovascular event is lacking.

Sep 1, 2011 Issue
Pharmacologic Treatment of Hyperlipidemia [Article]

Pharmacologic treatment of hyperlipidemia in conjunction with therapeutic lifestyle changes can be used for both primary and secondary prevention of cardiovascular disease. Statins have the most convincing data for primary prevention, especially for higher risk patients. Therefore, risk stratificati...

May 15, 2011 Issue
Primary Prevention of CVD: Treating Dyslipidemia [Clinical Evidence Handbook]

What are the effects of pharmacologic cholesterol-lowering interventions in persons at low, medium, and high risk of CHD? What are the effects of a reduced- or modified-fat diet in persons at risk of CHD?

Mar 15, 2011 Issue
Considerations for Safe Use of Statins: Liver Enzyme Abnormalities and Muscle Toxicitiy [Article]

Statins play an important role in the care of patients with cardiovascular disease and have a good safety record in clinical practice. The risk of hepatic injury caused by statins is estimated to be about 1 percent, similar to that of patients taking a placebo. Patients with transaminase levels no m...

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