Nov 15, 2005 Issue
Ezetimibe/Simvastatin (Vytorin) for Hypercholesterolemia [STEPS]

Low doses of ezetimibe/simvastatin provide greater improvements in lipid profile than simvastatin or atorvastatin monotherapy. Ezetimibe/simvastatin may be useful in patients who are unable to tolerate high-dose statin therapy. Combination ezetimibe-simvastatin is less expensive than adding ezetimib...

Jul 15, 2005 Issue
Colesevelam (WelChol) for Reduction of LDL Cholesterol [STEPS]

Colesevelam lowers LDL cholesterol levels a small amount (7 to 16 percent) when used alone and provides additional cholesterol lowering when added to statin therapy. It has a slightly beneficial effect on HDL cholesterol levels, has no effect on triglyceride levels, and is well tolerated.

Mar 15, 2005 Issue
Treatment of Cholesterol Abnormalities [Article]

Cardiovascular disease and its subset coronary heart disease are leading causes of morbidity and mortality in the United States and worldwide. In general, higher levels of low-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease, myocardial infarction, and ...

Oct 15, 2004 Issue
NCEP Issues Interim Guidelines on Management of Cholesterol [Practice Guidelines]

The National Cholesterol Education Program (NCEP) recently issued interim guidelines as an addendum to the 2002 Adult Treatment Panel III (ATP III) guidelines regarding the management of cholesterol.

Jun 15, 2004 Issue
Metabolic Syndrome: Time for Action [Article]

The constellation of dyslipidemia (hypertriglyceridemia and low levels of high-density lipoprotein cholesterol), elevated blood pressure, impaired glucose tolerance, and central obesity is identified now as metabolic syndrome, also called syndrome X. Soon, metabolic syndrome will overtake cigarette ...

Oct 15, 2003 Issue
Ezetimibe for Hypercholesterolemia. [STEPS]

Ezetimibe is safe and effective for lowering LDL cholesterol and triglyceride levels, but has not been shown to affect patient-oriented outcomes. It can be used as monotherapy or in combination with a low-dose statin, although the combination is more expensive than the maximum dose of the statin.

Mar 1, 2002 Issue
Cholesterol Treatment Guidelines Update [Article]

Hypercholesterolemia is one of the major contributors to atherosclerosis and coronary heart disease in our society. The National Cholesterol Education Program of the National Institutes of Health has created a set of guidelines that standardize the clinical assessment and management of hypercholeste...

Jan 15, 2002 Issue
Optimal Management of Cholesterol Levels and the Prevention of Coronary Heart Disease in Women [Article]

Coronary heart disease, the leading cause of death in women, is largely preventable. Lifestyle modifications (e.g., diet and exercise) are the cornerstone of primary and secondary prevention. Elevated levels of low-density lipoprotein cholesterol and triglycerides and low levels of high-density lipo...

Jan 15, 2002 Issue
Screening for Lipid Disorders in Adults: Recommendations and Rationale [U.S. Preventive Services Task Force]

This statement summarizes the current U.S. Preventive Services Task Force (USPSTF) recommendations for screening for lipid disorders and the supporting scientific evidence, and it updates the 1995 recommendations contained in the Guide to Clinical Preventive Services, second edition.

Jan 15, 2001 Issue
Effective Use of Statins to Prevent Coronary Heart Disease [Article]

Primary and secondary prevention trials have shown that use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (also known as statins) to lower an elevated low-density lipoprotein cholesterol level can substantially reduce coronary events and death from coronary heart disease. In 1987 and...

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