May 15, 2000 Issue
Combination Antihypertensive Drugs: Recommendations for Use [Article]

The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. A target blood pressure of less than 140/90 mm Hg is achieved in about 50 percent of patients treated with monotherapy; two or more agents from different pharmacologic classes are oft...

Sep 15, 1999 Issue
Angiotensin II Receptor Antagonists in the Treatment of Hypertension [Article]

The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VI) includes recommendations for the assessment of overall cardiovascular risk and the need for active antihypertensive drug therapy. Once the decision to initiate antihyp...

Jul 01, 1999 Issue
A Rational Approach to the Treatment of Hypertension in Special Populations [Article]

Hypertension in blacks is usually characterized by low renin, expanded volume and sensitivity to salt. Diuretics are the preferred initial therapy, but response to calcium channel antagonists is also good. The blood pressure response to monotherapy with beta blockers or angiotensin-converting enzyme...

Jun 1, 1999 Issue
Angiotensin-II Receptor Antagonists: Their Place in Therapy [Article]

Angiotensin-II receptor antagonists (or blockers) are a newer class of antihypertensive agents. These drugs are selective for angiotensin II (type 1 receptor); unlike angiotensin-converting enzyme inhibitors, they do not inhibit bradykinin metabolism or enhance prostaglandin synthesis. Angiotensin-I...

Mar 1, 1999 Issue
Hypertension Treatment and the Prevention of Coronary Heart Disease in the Elderly [Article]

Both isolated systolic hypertension (>140 mm Hg/<90 mm Hg) and systolic/diastolic hypertension (>140 mm Hg/>90 mm Hg) are major risk factors for cardiovascular disease in the elderly. Specific antihypertensive drug therapy is available if lifestyle interventions fail to reduce blood pressure to a no...

Oct 15, 1998 Issue
Treatment of Hypertension: Insights from the JNC-VI Report [Article]

The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VI) provides updated guidelines for the treatment of hypertension. Antihypertensive drug therapy may be initiated either after a trial of lifestyle modifications or immedi...

Apr 1, 1998 Issue
Calcium Channel Antagonists: Morbidity and Mortality - What's the Evidence? [Article]

Recent studies have shown an association between the use of calcium channel antagonists for the treatment of hypertension and an increased risk of myocardial infarction, gastrointestinal hemorrhage and cancer. The interpretation of the results of these studies and their application to clinical pract...

Mar 1, 1998 Issue
Managing the Patient with Hard-to-Control Hypertension [Article]

Less than 25 percent of patients with hypertension in the United States have their blood pressure under control, mainly because of inadequate or inappropriate therapy and noncompliance. Approximately one half of these treatment failures are related to factors such as cost and adverse effects of medi...

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