Immune Disorders

Oct 1, 2000 Issue
A Family Physicians' Guide to Monitoring Methotrexate [Article]

Methotrexate has a long history of use in the treatment of various immunologic diseases, including rheumatoid arthritis and psoriasis. Although the drug is usually prescribed by a subspecialist, a family physician may assume responsibility for monitoring methotrexate therapy. Major toxic effects, su...

Jan 15, 2000 Issue
American Thoracic Society Issues Consensus Statement on Sarcoidosis [Practice Guidelines]

The American Thoracic Society (ATS) has issued a consensus statement on sarcoidosis. The statement provides information on the epidemiology, pathogenesis, diagnosis and treatment of sarcoidosis.

Oct 1, 1999 Issue
An Approach to Diagnosis and Initial Management of Systemic Vasculitis [Article]

Systemic vasculitis occurs in a heterogeneous group of primary disorders or can be a manifestation of infection, an adverse drug reaction, malignancy or a connective tissue disease. A vasculitic process should be suspected in patients with unexplained ischemia or multiple organ involvement, especial...

Dec 01, 1998 Issue
Sarcoidosis: A Primary Care Review [Article]

Sarcoidosis is a multisystemic disorder of unknown etiology that most commonly affects adults between 20 and 40 years of age. Patients with sarcoidosis frequently present with bilateral hilar lymphadenopathy and pulmonary infiltration, and often with ocular and skin lesions. The diagnosis is establi...

Aug 01, 1998 Issue
Henoch-Schönlein Purpura: A Review [Article]

Henoch-Schönlein purpura is an IgA-mediated, autoimmune, hypersensitivity vasculitis of childhood that results in a triad of symptoms, including a purpuric rash occurring on the lower extremities, abdominal pain or renal involvement, and arthritis. However, any of the triad may be absent, which oft...

Jun 1, 1998 Issue
Treatment of Systemic Lupus Erythematosus: An Update [Article]

Systemic lupus erythematosus predominantly affects women and is more common in blacks. Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but re...

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