Liver Disorders

Jul 1, 2013 Issue
Nonalcoholic Fatty Liver Disease: Diagnosis and Management [Article]

Nonalcoholic fatty liver disease is characterized by excessive fat accumulation in the liver (hepatic steatosis). Nonalcoholic steatohepatitis is characterized by steatosis, liver cell injury, and inflammation. The mechanism of nonalcoholic fatty liver disease is unknown but involves the development...

Feb 1, 2013 Issue
Hereditary Hemochromatosis [Article]

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body’s regulation of iron. It is the most common genetic disease in whites. Men have a 24-fold increased rate of iron-overload disease compared with women. Persons who are homozygous for the HFE gene mutation C282Y compr...

Oct 15, 2012 Issue
Evaluation of Elevated Serum Transaminase Levels [FPIN's Clinical Inquiries]

The evaluation of patients with elevated transaminase levels should be individualized based on the presence of symptoms or physical examination findings that suggest serious disease or hepatic decompensation.

Sep 1, 2012 Issue
Weight Loss for Patients with Nonalcoholic Fatty Liver Disease [Cochrane for Clinicians]

There are insufficient high-quality studies to determine patient-oriented outcomes of weight loss for the treatment of fatty liver disease. Nonetheless, weight loss remains a reasonable goal because it may reduce liver inflammation and improve comorbidities. In two of the studies reviewed, liver enz...

Dec 15, 2011 Issue
Cirrhosis: Diagnosis, Management, and Prevention [Article]

Cirrhosis is the 12th leading cause of death in the United States. It accounted for 29,165 deaths in 2007, with a mortality rate of 9.7 per 100,000 persons. Alcohol abuse and viral hepatitis are the most common causes of cirrhosis, although nonalcoholic fatty liver disease is emerging as an increasi...

Nov 1, 2011 Issue
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels [Article]

Mild elevations in levels of the liver enzymes alanine transaminase and aspartate transaminase are commonly discovered in asymptomatic patients in primary care. Evidence to guide the diagnostic workup is limited. If the history and physical examination do not suggest a cause, a stepwise evaluation s...

Nov 15, 2006 Issue
Predicting Prognosis in Patients with End-stage Liver Disease [Point-of-Care Guides]

Two scoring systems are widely used to predict prognosis in patients with end-stage liver disease: the Model for End-Stage Liver Disease (MELD) and the Child-Turcotte-Pugh (CTP) score.

Sep 1, 2006 Issue
Cirrhosis and Chronic Liver Failure: Part II. Complications and Treatment [Article]

Major complications of cirrhosis include ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, portal hypertension, variceal bleeding, and hepatorenal syndrome. Diagnostic studies on ascitic fluid should include a differential leukocyte count, total protein level, a serum-ascites album...

Sep 1, 2006 Issue
Cirrhosis and Chronic Liver Failure: Part I. Diagnosis and Evaluation [Article]

Cirrhosis and chronic liver failure are leading causes of morbidity and mortality in the United States, with the majority of preventable cases attributed to excessive alcohol consumption, viral hepatitis, or nonalcoholic fatty liver disease. Cirrhosis often is an indolent disease; most patients rema...

Jun 1, 2006 Issue
Nonalcoholic Fatty Liver Disease [Article]

Nonalcoholic fatty liver disease is a common condition associated with metabolic syndrome. It is the most common cause of elevated liver enzymes in U.S. adults, and is diagnosed after ruling out other causes of steatosis (fatty infiltration of liver), particularly infectious hepatitis and alcohol ab...

Pages: Previous 1 2 3 Next

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now