May 1, 2018 Issue
Charcot Foot: Clinical Clues, Diagnostic Strategies, and Treatment Principles [Article]

Recognizing Charcot neuroarthropathy of the foot and ankle is critical because if untreated, patients are at risk of ulceration, infection, and amputation. Physicians should suspect Charcot foot in patients older than 40 years who present with peripheral neuropathy and acute swelling with associated erythema and warmth. The mainstay of treatment is immobilization in a total contact cast.

Dec 1, 2017 Issue
Topical Capsaicin for Treatment of Chronic Neuropathic Pain in Adults [Medicine by the Numbers]

Based on low-quality evidence, high-concentration capsaicin patches reduce neuropathic pain from herpes and human immunodeficiency virus infection by 30% to 50% compared with the low-concentration capsaicin control group.

Aug 1, 2016 Issue
Treating Painful Diabetic Peripheral Neuropathy: An Update [Article]

Painful diabetic neuropathic pain causes patients to experience burning pain, paresthesias, and numbness that progress from the feet and hands to the rest of the body. Although several therapeutic modalities are available for its treatment, many patients do not receive adequate care.

May 1, 2016 Issue
Alpha-Lipoic Acid for Treatment of Diabetic Peripheral Neuropathy [FPIN's Help Desk Answers]

Intravenous (IV) ALA can improve neuropathy symptoms when administered for three weeks, but symptom improvement with oral ALA is not clinically significant. There is no evidence evaluating long-term treatment.

Dec 1, 2015 Issue
Gabapentin for Chronic Neuropathic Pain [Medicine by the Numbers]

Studies show that 1 in 6 patients were helped with diabetic neuropathy and 1 in 8 were helped with postherpetic neuralgia. Find out more.

Oct 15, 2015 Issue
Unilateral Shoulder Weakness and Visual Deformity in a Young Military Recruit [Photo Quiz]

A man who had recently started an intensive exercise regimen had weakness in his arm and dull, achy shoulder pain. Examination revealed an obvious deformity.

Jul 1, 2015 Issue
The Role of Levetiracetam in Treating Chronic Neuropathic Pain Symptoms [Cochrane for Clinicians]

Based on low-quality evidence, levetiracetam was found to be ineffective for the treatment of chronic neuropathic pain symptoms. Moreover, patients who were taking levetiracetam experienced adverse effects at a significantly higher rate than those who were taking placebo.

May 1, 2015 Issue
Treatments for Sciatica [FPIN's Clinical Inquiries]

Surgical diskectomy can be offered to patients with refractory sciatica, but there is only modest, short-term improvement in leg pain and disability scores. Epidural steroid injections may be offered to patients with sciatica of more than six months' duration.

Feb 15, 2014 Issue
Unilateral Weakness of the Muscles of Facial Expression [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

Feb 1, 2014 Issue
Common Questions About Bell Palsy [Article]

Bell palsy is an acute affliction of the facial nerve, resulting in sudden paralysis or weakness of the muscles on one side of the face. Testing patients with unilateral facial paralysis for diabetes mellitus or Lyme disease is not routinely recommended. Patients with Lyme disease typically present ...

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