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Oct 1, 2008 Issue
ACP Guidelines on Screening for Osteoporosis in Men [Practice Guidelines]
Guidelines on screening for osteoporosis in men are available from the American College of Physicians (ACP). Although osteoporosis is commonly thought of as a disease that affects women, osteoporotic fractures also result in considerable morbidity and mortality in men.
Sep 1, 2008 Issue
Alendronate for Fracture Prevention in Postmenopause [Cochrane for Clinicians]
In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures (NNT = 100), b...
Zoledronic acid, in combination with calcium and vitamin D, will reduce the risk of vertebral fractures, and to a lesser extent, hip fractures in women with osteoporosis. It decreases subsequent fractures and mortality in high-risk patients who have had a hip fracture. Zoledronic acid may be most us...
Approximately one in six women will have a hip fracture during her lifetime, and approximately one in 35 of all women will die of complications from hip fracture.
The North American Menopause Society (NAMS) has updated its evidence-based guidelines on the diagnosis, prevention, and treatment of osteoporosis in postmenopausal women to address the need for standards of care as they relate to menopause-associated health conditions.
Ibandronate is a bisphosphonate that can be taken daily or monthly. The daily dosage has been shown to decrease vertebral fractures in women with osteoporosis and a history of previous vertebral fractures. Neither formulation has been shown to reduce the risk of hip fracture or other nonvertebral fr...
Osteoporosis is characterized by low bone mineral density and a deterioration in the microarchitecture of bone that increases its susceptibility to fracture. The World Health Organization defines osteoporosis as a bone mineral density that is 2.5 standard deviations or more below the reference mean ...
Calcium supplementation has a beneficial effect on bone density and may reduce vertebral fractures. It has no clear effect on nonvertebral fractures, although the number of patients studied may be too small to predict this outcome.
Teriparatide increases bone density in men and women with osteoporosis and has reduced the risk of new vertebral fractures in high-risk women. Its role in therapy is not clear. Due to its uncertain safety profile, lack of long-term experience, and high cost, it makes sense to reserve teriparatide fo...
Mar 15, 2004 Issue
ACOG Releases Guidelines for Clinical Management of Osteoporosis [Practice Guidelines]
The American College of Obstetricians and Gynecologists (ACOG) recently issued guidelines for the clinical management of osteoporosis in women, including recommendations for screening, prevention, and treatment.