Sep 01, 2021 Issue
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison [Article]

Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that present diagnostic and therapeutic challenges to the physician. Although many of their features overlap, they are two distinct conditions. KD is a febrile illness most commonly affecting ...

Apr 15, 2021 Issue
Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders [Article]

Hypermobile Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders are the most common symptomatic joint hypermobility conditions seen in clinical practice. Clinical features of hypermobile EDS include joint hypermobility, skin findings, and joint pains or recurrent dislocations. Hypermobile EDS and, less commonly, hypermobility spectrum disorders may be associated with extra-articular symptoms, including anxiety disorders, chronic pain, fatigue, orthostatic intolerance, functional gastrointestinal disorders, and bladder dysfunction. Goals of therapy are managing symptoms, preventing joint injury, and educating patients about their condition. Based on limited evidence, patients may benefit from physical and occupational therapy, psychological support, and self-management.

Aug 15, 2020 Issue
Paget Disease of Bone for Primary Care [Article]

Paget disease of bone is a benign disorder with focal areas of increased bone turnover in one or more skeletal sites. It usually affects older adults, and men have a slightly higher risk than women. The disease most often affects the pelvis, spine, skull, and long bones; pain is the most common symptom. Patients may be asymptomatic, with suspicion arising from elevated levels of serum alkaline phosphatase in routine blood work or incidental findings of radiographic abnormalities.

Aug 1, 2018 Issue
Rheumatologic Tests: A Primer for Family Physicians [Article]

Patients with a suspected connective tissue disorder should undergo serologic testing to confirm the diagnosis and in some cases, to monitor disease activity and predict flares. However, many serologic tests are nonspecific, and further testing may be necessary. Physicians should order these tests only when patients have a high pretest probability of a specific connective tissue disorder.

Apr 1, 2018 Issue
Rheumatoid Arthritis: Common Questions About Diagnosis and Management [Article]

Early diagnosis and treatment of rheumatoid arthritis are associated with better outcomes for patients. Methotrexate is the disease-modifying antirheumatic drug of choice, although other nonbiologic and biologic agents are available. Patients should be screened for chronic infections before beginning treatment for rheumatoid arthritis.

Nov 15, 2017 Issue
Spondyloarthritis: NICE Releases Guidelines on Diagnosis and Treatment [Practice Guidelines]

Spondyloarthritis comprises inflammatory disorders that have some overlapping characteristics. The National Institute for Health and Care Excellence (NICE) released a guideline on diagnosing and treating spondyloarthritis.

Sep 1, 2016 Issue
Nontender Elbow Nodules [Photo Quiz]

A woman presented with long-standing pain and stiffness in multiple joints. She had tenderness of metacarpophalangeal joints and nodules over the extensor surfaces of her elbows.

Aug 15, 2016 Issue
Joint Pain and Fatigue: It Could Be Anything [Close-ups]

Diagnosed with lupus, a physician reflects on the shift from usual aches and pains to fatigue that puts life on hold.

Feb 15, 2016 Issue
A Resolving Rash on the Breast [Photo Quiz]

A woman presented with a rash that began as a large plaque affecting one-fourgh of her breast then decreased to a small plaque affecting only the nipple.

Jul 1, 2015 Issue
Differential Diagnosis of Polyarticular Arthritis [Article]

Many conditions can cause joint pain. Diagnosis requires distinguishing between inflammatory and noninflammatory arthritis, as well as recognizing nonarticular conditions. Learn the common symptoms and signs of the possible etiologies of joint pain.

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