Seizure Disorders

May 1, 2018 Issue
Antiepileptic Drug Monotherapy for Epilepsy [Cochrane for Clinicians]

In patients with partial-onset (focal) seizures, levetiracetam (Keppra), lamotrigine (Lamictal), and carbamazepine (Tegretol) were associated with the longest time to treatment withdrawal (i.e., the recommended patient-oriented outcome measure that balances tolerability with effectiveness).

Jul 15, 2017 Issue
Epilepsy: Treatment Options [Article]

Routinely initiating treatment with an antiepileptic after a first seizure is not recommended in part because of the potential for adverse effects. Identifying when patients will benefit from pharmacotherapy or other adjunctive options requires ongoing careful assessment of risk factors.

Feb 1, 2017 Issue
Antiepileptic Drugs After First Unprovoked Seizure [Medicine by the Numbers]

The decision to start an antiepileptic drug after a first unprovoked seizure has long been a clinically challenging one.

Jun 1, 2016 Issue
When to Discontinue Antiepileptic Drug Therapy for Patients in Remission [Cochrane for Clinicians]

Children with epilepsy should be seizure-free for at least two years before stopping antiepileptic drug therapy, especially those who have partial seizures or a history of abnormal electroencephalography (EEG) results.

Nov 1, 2015 Issue
Unprovoked First Seizures in Adults: Management Recommendations from the AAN [Practice Guidelines]

This guideline from the Academy of Neurology (AAN) provides information on prognosis and management options for unprovoked first seizures in adults.

Jan 15, 2015 Issue
Absence Seizures in Children [Clinical Evidence Handbook]

What are the effects of treatments for typical absence seizures in children?

Aug 15, 2012 Issue
Evaluation of First Nonfebrile Seizures [Article]

Nonfebrile seizures may indicate underlying disease or epilepsy. The patient history can often distinguish epileptic seizures from nonepileptic disorders by identifying the events directly preceding the convulsion, associated conditions, and details of the seizure, including triggers, length, and ty...

Jan 15, 2012 Issue
Febrile Seizures: Risks, Evaluation, and Prognosis [Article]

Febrile seizures are common in the first five years of life, and many factors that increase seizure risk have been identified. Initial evaluation should determine whether features of a complex seizure are present and identify the source of fever. Routine blood tests, neuroimaging, and electroencepha...

Feb 15, 2011 Issue
Epilepsy (Generalized and Partial) [Clinical Evidence Handbook]

What are the effects of monotherapy in generalized epilepsy (tonic-clonic type)? What are the effects of additional treatments in persons with drug-resistant generalized epilepsy?

Nov 1, 2010 Issue
Usefulness of Measuring Antiepileptic Medication Blood Levels in Patients with Epilepsy [Cochrane for Clinicians]

When treating a patient for epilepsy, there is not enough evidence to indicate if optimal seizure control is best obtained by routinely measuring medication levels compared with making adjustments based on the clinical picture.

Pages: 1 2 3 Next

Email Alerts

Don't miss a single issue. Sign up for the free AFP email table of contents.

Sign Up Now