ITEMS IN AFP WITH KEYWORD:
In patients with partial-onset (focal) seizures, levetiracetam (Keppra), lamotrigine (Lamictal), and carbamazepine (Tegretol) were associated with the longest time to treatment withdrawal (i.e., the recommended patient-oriented outcome measure that balances tolerability with effectiveness).
Routinely initiating treatment with an antiepileptic after a first seizure is not recommended in part because of the potential for adverse effects. Identifying when patients will benefit from pharmacotherapy or other adjunctive options requires ongoing careful assessment of risk factors.
Feb 1, 2017 Issue
Antiepileptic Drugs After First Unprovoked Seizure [Medicine by the Numbers]
The decision to start an antiepileptic drug after a first unprovoked seizure has long been a clinically challenging one.
Jun 1, 2016 Issue
When to Discontinue Antiepileptic Drug Therapy for Patients in Remission [Cochrane for Clinicians]
Children with epilepsy should be seizure-free for at least two years before stopping antiepileptic drug therapy, especially those who have partial seizures or a history of abnormal electroencephalography (EEG) results.
This guideline from the Academy of Neurology (AAN) provides information on prognosis and management options for unprovoked first seizures in adults.
What are the effects of treatments for typical absence seizures in children?
Nonfebrile seizures may indicate underlying disease or epilepsy. The patient history can often distinguish epileptic seizures from nonepileptic disorders by identifying the events directly preceding the convulsion, associated conditions, and details of the seizure, including triggers, length, and ty...
Febrile seizures are common in the first five years of life, and many factors that increase seizure risk have been identified. Initial evaluation should determine whether features of a complex seizure are present and identify the source of fever. Routine blood tests, neuroimaging, and electroencepha...
What are the effects of monotherapy in generalized epilepsy (tonic-clonic type)? What are the effects of additional treatments in persons with drug-resistant generalized epilepsy?
Nov 1, 2010 Issue
Usefulness of Measuring Antiepileptic Medication Blood Levels in Patients with Epilepsy [Cochrane for Clinicians]
When treating a patient for epilepsy, there is not enough evidence to indicate if optimal seizure control is best obtained by routinely measuring medication levels compared with making adjustments based on the clinical picture.