Sickle Cell Disease

Dec 15, 2015 Issue
Management of Sickle Cell Disease: Recommendations from the 2014 Expert Panel Report [Article]

Recently published guidelines provide important recommendations for health maintenance, acute care, and monitoring of disease-modifying therapy in persons with sickle cell disease. This overview highlights some of the most important clinical activities that can and should be carried out in the community care setting.

Mar 15, 2009 Issue
Screening for Sickle Cell Disease in Newborns [Putting Prevention into Practice]

Case study: E.C. is a 28-year-old black woman. She and her husband arrive for their three-day-old son’s appointment. The infant, L.C., was born at home with a lay midwife after an uncomplicated pregnancy.

May 1, 2008 Issue
Screening for Sickle Cell Disease in Newborns: Recommendation Statement [U.S. Preventive Services Task Force]

This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for sickle cell disease in newborns and the supporting scientific evidence; it also updates the 1996 recommendations contained in the Guide to Clinical Preventive Services, 2nd ed.

Jul 15, 2006 Issue
Opportunities to Improve Outcomes in Sickle Cell Disease [Article]

Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The pathophysiology involves abnormalities not just in red blood cells but also vascular endothelium, white blood cell function, coagulation, and inflammatory response. Known sequelae of sickle cell disease include invasive...

Sep 15, 2000 Issue
Sickle Cell Disease in Childhood: Part II. Diagnosis and Treatment of Major Complications and Recent Advances in Treatment [Article]

Treatment advances over the past 25 years have significantly decreased morbidity and mortality in children with sickle cell disease. Aggressive management of fever, early diagnosis of acute chest syndrome, judicious use of transfusions and proper treatment of pain can improve quality of life and pro...

Sep 1, 2000 Issue
Sickle Cell Disease in Childhood: Part I. Laboratory Diagnosis, Pathophysiology and Health Maintenance [Article]

Over the past 25 years, morbidity and mortality have decreased significantly in children with sickle cell disease, and screening tests are now available to diagnose the disease in newborns. The incidence of sepsis caused by pneumococcal and Haemophilus influenzae infections has declined because of t...

Mar 1, 2000 Issue
Approach to Vaso-occlussive Crisis in Adults with Sickle Cell Disease [Article]

The vaso-occlusive crisis, or sickle cell crisis, is a common painful complication of sickle cell disease in adolescents and adults. Acute episodes of severe pain (crises) are the primary reason that these patients seek medical care in hospital emergency departments. Frequently, however, the pain is...

Mar 1, 2000 Issue
Management of Pain in Sickle Cell Disease [Practice Guidelines]

The American Pain Society (APS) has released a new guideline to aid physicians and other health care professionals in the management of patients with acute and chronic pain associated with sickle cell disease.

Jun 1, 1999 Issue
Chronic Non-healing Ulcers [Photo Quiz]

Photo Quiz presents readers with a clinical challenge based on a photograph or other image.

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