Vascular Disorders

Jun 1, 2019 Issue
Varicose Veins: Diagnosis and Treatment [Article]

The pathophysiology of varicose veins involves a genetic predisposition, incompetent valves, weakened vascular walls, and increased intravenous pressure. Established risk factors include family history of venous disease, female sex, older age, chronically increased intra-abdominal pressure, deep venous thrombosis, and arteriovenous shunting. Current guidelines recommend endovenous thermal ablation as first-line therapy for nonpregnant patients, followed by endovenous sclerotherapy and surgery. Conservative measures are recommended for patients who are not candidates for endovenous or surgical management, do not desire intervention, or are pregnant.

Nov 1, 2018 Issue
Abrupt Rash with Painful, Nonpruritic Purpura on the Lower Extremities [Photo Quiz]

Oct 1, 2017 Issue
In Very High-Risk Patients with Vascular Disease, Evolocumab Slightly Reduces Nonfatal MI But Not Mortality [POEMs]

In an extremely high-risk group of patients with known vascular disease, taking evolocumab instead of placebo in addition to standard statin therapy for slightly more than two years will prevent one myocardial infarction (MI) for every 83 persons treated and prevent one stroke for every 250 persons treated.

May 15, 2017 Issue
Venous Leg Ulcers [Clinical Evidence Handbook]

What are the effects of treatments for venous leg ulcers? What are the effects of various interventions for venous leg ulcers?

Jan 15, 2017 Issue
Giant Cell Arteritis: Biopsy After Corticosteroid Initiation [FPIN's Clinical Inquiries]

Corticosteroid therapy in patients with suspected giant cell arteritis should not degrade the accuracy of temporal artery biopsy if the biopsy is performed within four weeks of corticosteroid initiation. Temporal artery biopsy can be performed up to four weeks after starting high-dose corticosteroid therapy.

Mar 15, 2016 Issue
American Academy of Pediatrics Releases Report on Infantile Hemangiomas [Practice Guidelines]

The American Academy of Pediatrics has published a report to provide an update on diagnosing and managing infantile hemangiomas.

Aug 15, 2015 Issue
Discoloration in the Hands [Photo Quiz]

A woman with systemic lupus erythematosus had pain in her hands and discoloration on the tips of her fingers and toes when exposed to cold.

Aug 15, 2015 Issue
Vorapaxar (Zontivity) for the Prevention of Thrombotic Cardiovascular Events [STEPS]

Vorapaxar should be limited to select patients with a history of MI or peripheral arterial disease who desire additional treatment for the prevention of MI.

Dec 1, 2014 Issue
Painless Vision Loss [Photo Quiz]

A woman presented with gradually decreasing vision in her right eye. Retinal examination revealed intraretinal hemorrhages in the right eye with edema.

Nov 1, 2014 Issue
Niacin Does Not Improve Clinical Outcomes in Patients with Vascular Disease [POEMs]

This large, adequately powered trial did not find any clinically meaningful benefit to the use of niacin in patients who are already taking a statin, even with several study design features that should bias the result in favor of niacin. Niacin should not be prescribed to reduce the risk of cardiova...

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