Sep 15, 2016 Issue
Medications for Chronic Asthma [Article]

Therapeutic agents used in the management of chronic asthma aim to prevent symptoms by controlling airway inflammation and hyperreactivity. Medication regimens are organized in stepwise approaches based on patient age. Data regarding the safety and efficacy of popular complementary and alternative asthma treatments are largely unavailable.

Sep 1, 2016 Issue
Inhaled Fluticasone-Salmeterol Better Than Fluticasone Alone for Moderate to Severe Asthma [POEMs]

The combination of fluticasone and salmeterol (Advair), with the steroid dose adjusted for disease severity, reduces the number of severe asthma exacerbations more than fluticasone (Flovent) alone (number needed to treat [NNT] = 50 over 26 weeks), with no difference in terms of potential harms, such as intubation or asthma-related death.

Aug 15, 2016 Issue
Single-Dose Dexamethasone Equals Three Days of Steroids in Children with Acute Asthma [POEMs]

In addition to usual beta-agonist treatment, a single dose of oral dexamethasone is as effective as three days of prednisolone (with less vomiting) in decreasing respiratory symptoms without increasing hospitalizations, follow-up visits, and days lost from school. Additional treatment with a steroid...

Jul 1, 2016 Issue
Intermittent Inhaled Corticosteroid Therapy for Mild Persistent Asthma in Children and Adults [Cochrane for Clinicians]

Intermittent inhaled corticosteroid therapy reduces the risk of asthma exacerbations in children and adults with mild persistent asthma. Intermittent use appears to be safe in these patients.

Apr 1, 2016 Issue
Leukotriene Receptor Antagonists in the Treatment of Acute Asthma [Medicine by the Numbers]

Studies show there were no patient-important benefits and no hospital admissions were prevented. Want to know more?

Oct 1, 2014 Issue
Safety of Long-Acting Beta Agonists in Adults with Asthma [Cochrane for Clinicians]

LABAs appear to be safe when used with inhaled corticosteroids. LABA monotherapy is associated with an increase in asthma-related mortality and nonfatal serious adverse events, but not in all-cause mortality.

Mar 15, 2014 Issue
PPIs, Childhood Asthma, and the Problem of Therapeutic Creep [AFP Journal Club]

The use of a therapy in patients one would intuitively think might benefit, but in whom no benefit has been documented, is called therapeutic creep. The use of proton pump inhibitors for poorly controlled asthma is an example of this phenomenon.

Jul 15, 2013 Issue
Acute Asthma and Other Recurrent Wheezing Disorders in Children [Clinical Evidence Handbook]

What are the effects of treatments for acute asthma in children?

Mar 1, 2013 Issue
Physical Training for Patients with Asthma [Cochrane for Clinicians]

Physical training lasting for at least 20 to 30 minutes, two to three times a week for at least six weeks, improves physical fitness in patients with asthma. Physical training is not associated with worsening of asthma symptoms, and it improves health-related quality of life.

Feb 1, 2013 Issue
Physician-, Biomarker-, and Symptom-Based Adjustment of Inhaled Steroids All Similar for Adult Asthma Control [POEMs]

Symptom-based dose adjustment of inhaled steroids resulted in similar treatment outcomes compared with a dosing strategy based on physician assessment using widely distributed standard national guidelines, and compared with a biomarker-based strategy using exhaled nitric oxide.

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