ITEMS IN AFP WITH KEYWORD:
Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.
In this systematic review of patients with rheumatoid arthritis, ultrasonography was reasonably accurate compared with magnetic resonance imaging (MRI) in detecting synovitis in fingers and wrists. The use of MRI as a reference standard is convenient, but problematic.
May 1, 2018 Issue
Effectiveness and Safety of Celecoxib for the Treatment of Rheumatoid Arthritis [Cochrane for Clinicians]
Compared with placebo, celecoxib improves pain (number needed to treat [NNT] = 4) and clinical symptoms (NNT = 7), but it has no effect on physical function in patients with RA.
Early diagnosis and treatment of rheumatoid arthritis are associated with better outcomes for patients. Methotrexate is the disease-modifying antirheumatic drug of choice, although other nonbiologic and biologic agents are available. Patients should be screened for chronic infections before beginning treatment for rheumatoid arthritis.
Methotrexate monotherapy demonstrated statistically significant and clinically relevant improvement of symptoms and physical function compared with placebo at 12 to 52 weeks. Multiple adverse effects were reported with methotrexate use, and patients were twice as likely to discontinue methotrexate therapy when compared with placebo.
Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis. Women, smokers, and those with a family history of the disease are most often affected. Criteria for diagnosis include having at least one joint with definite swelling that is not explained by another disease. The l...
Adalimumab used alone offers little benefit over the traditional first-line agent, methotrexate. However, it increases remission rates when combined with methotrexate in early aggressive rheumatoid arthritis and when combined with traditional DMARDs in those who have not derived benefit from existin...
May 15, 2008 Issue
Predicting Rheumatoid Arthritis Risk in Adults with Undifferentiated Arthritis [Point-of-Care Guides]
Early use of disease-modifying antirheumatic drugs (DMARDs) markedly reduces inflammation and joint destruction associated with RA.1,2 Therefore, with early diagnosis of RA and appropriate use of DMARDs, there is a window of opportunity to change the clinical course of this disabling disease.
Jun 15, 2007 Issue
Ophthalmologic Examinations in Children with Juvenile Rheumatoid Arthritis [Practice Guidelines]
Guidelines on the use and frequency of ophthalmologic examinations in children with juvenile rheumatoid arthritis are available from the American Academy of Pediatrics (AAP).
Combined with methotrexate, subcutaneous adalimumab at a dosage of 40 mg every two weeks slows the progression of rheumatoid arthritis at one year. The combination is more effective than adalimumab monotherapy. Limited evidence suggests that adalimumab is also safe and effective when combined with o...