ITEMS IN AFP WITH KEYWORD:
Rheumatoid arthritis is a chronic inflammatory disease characterized by uncontrolled proliferation of synovial tissue and a wide array of multisystem comorbidities. Prevalence is estimated to be 0.8 percent worldwide, with women twice as likely to develop the disease as men. Untreated, 20 to 30 perc...
Feb 1, 2004 Issue
Are Selective COX-2 Inhibitors as Effective as NSAIDs in Patients with Rheumatoid Arthritis? [FPIN's Clinical Inquiries]
The efficacy of COX-2 inhibitors is similar to that of nonselective NSAIDs in reducing the symptoms of rheumatoid arthritis.
What are the effects of treatments?
Compared with placebo, leflunomide improves clinical outcomes and delays radiologic progression of rheumatoid arthritis. After two years of treatment, leflunomide is as safe as sulfasalazine and more effective. Leflunomide's efficacy and adverse events are similar to those of methotrexate. Leflunomi...