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Dec 1, 2016 Issue
Aripiprazole vs. Placebo or Haloperidol for Schizophrenia [Medicine by the Numbers]
Aripiprazole was shown to have one major benefit over placebo, but favorable outcomes with haloperidol throw its effectiveness into question. Are the differences merely anomalies?
Learn about the latest diagnostic criteria from the DSM 5, and how to choose between antipsychotic medications.
Feb 1, 2011 Issue
Clozapine vs. Other Atypical Antipsychotics for Schizophrenia [Cochrane for Clinicians]
Although further trials are needed, there is some evidence that clozapine is slightly more effective than risperidone (Risperdal). Fewer participants taking clozapine dropped out of studies because of lack of effectiveness compared with those taking risperidone (number needed to treat = 11; 95% conf...
What are the effects of treatments to reduce relapse rates in persons with schizophrenia? What are the effects of interventions in persons with schizophrenia who are resistant to standard antipsychotics? What are the effects of interventions to improve adherence to medication?
Jun 1, 2010 Issue
Aripiprazole vs. Other Atypical Antipsychotics for Schizophrenia [Cochrane for Clinicians]
Aripiprazole is less effective in treating schizophrenia than olanzapine (Zyprexa), but has fewer metabolic and sedative adverse effects. There is no difference in effectiveness between aripiprazole and risperidone (Risperdal); however, aripiprazole may be associated with less dystonia, smaller incr...
Compared with placebo, risperidone improves symptoms based on some disease-specific symptom scores for schizophrenia. However, it does not appear to improve symptoms on a more important Clinical Global Impression scale.
Schizophrenia is a debilitating mental illness that affects 1 percent of the population in all cultures. It affects equal numbers of men and women, but the onset is often later in women than in men. Schizophrenia is characterized by positive and negative symptoms. Positive symptoms include hallucina...