• PREPARE-PeRson EmPowered Asthma RElief


    Asthma affects more than 25 million people in the U.S. African-American and Hispanic/Latino populations are hard hit by asthma. Asthma exacerbations lead to days lost from work, interfere with people’s performance, and account for 50 percent of asthma healthcare costs.

    Patient Activated Rescue Therapy with Inhaled Corticosteroids (PARTICS), the combination of SABA and ICS for rescue therapy, was effective in a smaller very tightly controlled clinical trial. PARTICS decreased the patients’ number of asthma exacerbations requiring steroids, ED visits or hospitalizations. This study will evaluate whether the additional use of an inhaled corticosteroid (ICS) whenever a person decides they need to use their short-acting beta agonists (SABA) for rescue therapy improves asthma outcomes in real-world situations. This study aims to answer this important question: Among African-American and Hispanic/Latino adults, can a PARTICS strategy in addition to provider education reduce exacerbations better than provider education alone?

    Specific Aims and Objectives

    Specific Aim 1: To assess whether a Patient Activated, Reliever-Triggered Inhaled CorticoSteroid (PARTICS) strategy can reduce asthma morbidity in this population.

    • Our primary outcome will be asthma exacerbations which have been shown to be important to patients and healthcare stakeholders.
    • Our secondary outcomes will include additional outcomes important to patients such as days lost from work or school, asthma control, and asthma related quality of life.

    Specific Aim 2: To examine whether the effectiveness of a Patient Activated, Reliever-Triggered ICS (PARTICS) strategy differs between African American or Hispanic/Latino adults or by smoking status.

    Exploratory Aim: To examine whether particular patient clinical characteristics (e.g. prior exacerbations) or specific barriers to adherence (e.g. beliefs, depression) impact the effectiveness of a PARTICS approach in these populations.

    This is a patient-level randomized pragmatic study.


    This project is from June 2016 - June 2021.


    Recruiting and enrolling practices

    Key Findings and Publications

    Check back later for key findings.

    Contact Information

    For additional information about this study, please contact:

    Jennifer Carroll, MD, MPH
    AAFP National Research Network
    (800) 274-2237, ext. 3151

    Brian Manning, MPH, CHES
    Associate Research Director
    AAFP National Research Network
    (800) 274-2237, ext. 3179

    Joel Shields, MA
    Sr. Research Project Coordinator
    AAFP National Research Network
    (800) 274-2237, ext. 3183

    This study is funded by grants from PCORI