• Rationale and Comments

    Up to 50% of children develop musculoskeletal pain. There is no evidence that autoantibody panel testing in the absence of history or physical exam evidence of a rheumatologic disease enhances the diagnosis of children with isolated musculoskeletal pain. Autoantibody panels are expensive; evidence has demonstrated cost reduction by limiting autoantibody panel testing. Thus, autoantibody panels should be ordered following confirmed ANA positivity or clinical suspicion that a rheumatologic disease is present in the child.

    Sponsoring Organizations

    • American College of Rheumatology—Pediatric Rheumatology


    • Agency for Healthcare Research and Quality


    • Rheumatologic


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