Rationale and Comments
Up to 50% of children develop musculoskeletal pain. There is no evidence that autoantibody panel testing in the absence of history or physical exam evidence of a rheumatologic disease enhances the diagnosis of children with isolated musculoskeletal pain. Autoantibody panels are expensive; evidence has demonstrated cost reduction by limiting autoantibody panel testing. Thus, autoantibody panels should be ordered following confirmed ANA positivity or clinical suspicion that a rheumatologic disease is present in the child.
- American College of Rheumatology—Pediatric Rheumatology
- Agency for Healthcare Research and Quality
- Wong KO, Bond K, Homik J, Ellsworth JE, Karkhaneh M, Ha C, Dryden DM. Antinuclear antibody, rheumatoid factor, and cyclic-citrullinated peptide tests for evaluating musculoskeletal complaints in children. Comparative Effectiveness Review No. 50. AHRQ Publication No. 12-EHC015-EF. Rockville, Md.: Agency for Healthcare Research and Quality. March 2012.
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